| Title: |
Persistent T Cell Immunity Following Nipah Virus Infection: Evidence From Malaysian Survivors |
| Authors: |
Ibrahim, Puteri Ainaa S; Ong, Hui Ming; Cheong, Heng Choon; Tan, Chong Tin; Schee, Jie Ping; Avumegah, Michael Selorm; Wong, Won Fen; Chang, Li-Yen |
| Contributors: |
Coalition for Epidemic Preparedness Innovation; UMSC; CA.R.E. Fund |
| Source: |
The Journal of Infectious Diseases ; ISSN 0022-1899 1537-6613 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Nipah virus (NiV) induces strong humoral immunity, but the durability of NiV-specific memory T-cell responses remains unclear. We characterized cellular immunity approximately 25 years after infection in 4 survivors of the 1998 Malaysian outbreak. PBMCs were stimulated with overlapping peptide mini-pools spanning the NiV fusion (NiV-F) and attachment (NiV-G) glycoproteins, and responses were assessed using enzyme-linked immune absorbent spot and intracellular cytokine staining. Durable cytokine-producing T-cell responses were detected, with immunodominant epitopes in the NiV-G ectodomain. Survivors with neurological sequelae exhibited stronger T-cell responses and cognitive impairment, highlighting persistent cellular immunity decades after infection with implications for vaccine development. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/infdis/jiag017 |
| DOI: |
10.1093/infdis/jiag017/66301647/jiag017.pdf |
| Availability: |
https://doi.org/10.1093/infdis/jiag017; https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiag017/66301647/jiag017.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.2962CFE6 |
| Database: |
BASE |