| Title: |
312. Chlorhexidine Gluconate (CHG) Skin Concentration Measurement and Feedback in Hematology-Oncology and Hematopoietic Stem Cell Transplant (HO/HSCT) Units: A Multicenter Study |
| Authors: |
Rhee, Yoona; Thotapalli, Lahari; Schoeny, Michael; Babiker, Ahmed; Dubberke, Erik; Fridkin, Scott; Gettler, Erin; Leekha, Surbhi; Warren, David K; Ziegler, Matthew J; Addison, Rachel; Foy, Katherine; Froilan, Mary Carl; Habrock-Bach, Tracey; Huang, Elizabeth C; King, McKenzi; Newman, Michelle; Ney, Katheryn; Suchindran, Deepti; Tolomeo, Pam C; Jung, Jae; Shah, Maitri; Gough, Ellen; Hayden, Mary K; Lin, Michael Y |
| Source: |
Open Forum Infectious Diseases ; volume 13, issue Supplement_1 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Background The quality of CHG bathing for infection prevention in HO/HSCT units is uncertain, as patients are often self-bathing. We assessed CHG bathing quality by measuring patients’ CHG skin concentrations at baseline and then evaluated whether feedback of results to unit leadership/staff could guide improvement.Table.Demographics and Clinical Factors for Patients in Hematology-Oncology/Hematopoietic Stem Cell Transplant Units from Six Hospitals (N=736)Figure 1.Baseline Chlorhexidine Gluconate Skin Concentrations in Six Hematology-Oncology/Hematopoietic Stem Cell Transplant Units (N=379) Methods We conducted 6 point prevalence surveys from 9/2023 – 10/2024 in HO/HSCT units that performed routine CHG bathing at 6 hospitals. During each survey, we collected swab samples of patients’ skin (neck, axilla, inguinal region) and clinical data. We used a colorimetric assay to measure CHG skin concentrations (detection range ≥4.9 to 20,000 µg/ml). During surveys 1-3 (baseline period), CHG concentrations were measured but not shared. During surveys 4-6 (intervention period), summary CHG concentrations from baseline and after each intervention period survey were shared with unit leadership/staff, who led local quality improvement initiatives. We used linear and logistic regression to model outcomes, controlling for clustering as appropriate.Figure 2.Modeled Chlorhexidine Gluconate Skin Concentrations between Baseline and Intervention Periods in Hematology-Oncology/Hematopoietic Stem Cell Transplant Units from Six Hospitals (N=736) Results Six units participated (median 34 beds/unit); 3 units only used 2% CHG-impregnated cloth, and 3 units used bathing approaches that included other CHG formulations (4% CHG liquid or foam). Of 949 eligible patients, 83% consented to participate; after deduplication, 736 unique patients were analyzed (Table). 87% of patients reported using CHG. At baseline, 22% of 379 patients had undetectable CHG skin concentrations on all 3 body sites; CHG concentrations varied by unit ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf695.108 |
| Availability: |
https://doi.org/10.1093/ofid/ofaf695.108; https://academic.oup.com/ofid/article-pdf/13/Supplement_1/ofaf695.108/66343654/ofaf695.108.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.2967C19C |
| Database: |
BASE |