| Title: |
FROM BATTLEFIELD TO CHRONIC PAIN: RISK FACTORS AFTER COMBAT-RELATED EXTREMITY INJURIES — A MULTICENTER COHORT STUDY ; ВІД ПОЛЯ БОЮ ДО ХРОНІЧНОГО БОЛЮ: ФАКТОРИ РИЗИКУ ПІСЛЯ БОЙОВИХ УШКОДЖЕНЬ КІНЦІВОК — МУЛЬТИЦЕНТРОВЕ КОГОРТНЕ ДОСЛІДЖЕННЯ |
| Authors: |
Strokan, Andrii M.; Dmytriiev, Dmytro V.; Khomenko, Andrii M. |
| Source: |
Clinical and Preventive Medicine; No 1 (2026): Clinical and Preventive Medicine; 41-47 ; Клиническая и профилактическая медицина; № 1 (2026): Clinical and Preventive Medicine; 41-47 ; Клінічна та профілактична медицина; № 1 (2026): Клінічна та профілактична медицина; 41-47 ; 2616-4868 ; 10.31612/2616-4868.1.2026 |
| Publisher Information: |
State Institution of Science "Center of innovative healthcare technologies" State Administrative Department |
| Publication Year: |
2026 |
| Collection: |
Clinical and Preventive Medicine (E-Journal) / Клінічна та профілактична медицина |
| Subject Terms: |
combat-related injury; chronic pain; extremity trauma; peripheral nerve injury; regional anesthesia; military medicine; pain chronification; multicenter study; бойова травма; хронічний біль; ушкодження кінцівок; периферичні нерви; регіонарна анестезія; військова медицина; хронізація болю; мультицентрове дослідження |
| Description: |
Introduction. Chronic pain is a frequent and disabling consequence of combat-related extremity injuries. However, data on modifiable and non-modifiable risk factors for pain chronification in military trauma populations remain limited. Aim. To identify risk factors associated with the development of chronic pain after combat-related extremity injuries and to assess the impact of injury characteristics and early treatment strategies on pain outcomes. Materials and methods. This multicenter observational cohort study included 322 patients with combat-related extremity injuries treated at three tertiary care centers. Demographic, injury-related, and treatment-related variables were prospectively collected. Chronic pain persisting for ≥3 months after injury was the primary outcome. Univariate analyses were followed by multivariable logistic regression to identify independent predictors of chronic pain development. Results. Chronic pain developed in 98 patients (30.4%). In multivariable analysis, peripheral nerve injury (OR 2.78, 95% CI 1.68–4.60), infectious complications (OR 2.14, 95% CI 1.29–3.55), number of surgical procedures (OR 1.29 per procedure, 95% CI 1.14–1.47), and delayed initiation of analgesia (>6 hours) (OR 1.71, 95% CI 1.05–2.78) were independently associated with chronic pain. Use of regional anesthesia during the acute phase was associated with a reduced risk of chronic pain (OR 0.66, 95% CI 0.43–0.99). Conclusions. Approximately one-third of patients developed chronic pain following combat-related extremity injuries. Both injury severity and early treatment-related factors contribute to pain chronification. Optimization of early analgesia, prevention of infectious complications, and broader use of regional anesthesia may reduce the long-term burden of chronic pain in military trauma survivors. ; Вступ. Хронічний біль є частим і інвалідизуючим наслідком бойових ушкоджень кінцівок. Водночас дані щодо модифікованих та немодифікованих факторів ризику хронізації болю у пацієнтів із військовою ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://cp-medical.com/index.php/journal/article/view/707/629 |
| DOI: |
10.31612/2616-4868.1.2026.05 |
| Availability: |
http://cp-medical.com/index.php/journal/article/view/707; https://doi.org/10.31612/2616-4868.1.2026.05 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0 |
| Accession Number: |
edsbas.297C653D |
| Database: |
BASE |