| Title: |
A double dissociation between semantic and spatial cognition in visual to default network pathways |
| Authors: |
Gonzalez Alam, TRJ; Krieger-Redwood, K; Varga, D; Gao, Z; Horner, A; Hartley, T; Thiebaut de Schotten, M; Sliwinska, MW; Pitcher, D; Margulies, DS; Smallwood, J; Jefferies, E |
| Publisher Information: |
eLife Sciences Publications |
| Publication Year: |
2025 |
| Collection: |
Liverpool John Moores University: LJMU Research Online |
| Subject Terms: |
BF Psychology |
| Description: |
Processing pathways between sensory and default mode network (DMN) regions support recognition, navigation, and memory but their organisation is not well understood. We show that functional subdivisions of visual cortex and DMN sit at opposing ends of parallel streams of information processing that support visually-mediated semantic and spatial cognition, providing convergent evidence from univariate and multivariate task responses, intrinsic functional and structural connectivity. Participants learned virtual environments consisting of buildings populated with objects, drawn from either a single semantic category or multiple categories. Later, they made semantic and spatial context decisions about these objects and buildings during functional magnetic resonance imaging. A lateral ventral occipital to frontotemporal DMN pathway was primarily engaged by semantic judgements, while a medial visual to medial temporal DMN pathway supported spatial context judgements. These pathways had distinctive locations in functional connectivity space: the semantic pathway was both further from unimodal systems and more balanced between visual and auditory-motor regions compared with the spatial pathway. When semantic and spatial context information could be integrated (in buildings containing objects from a single category), regions at the intersection of these pathways responded, suggesting that parallel processing streams interact at multiple levels of the cortical hierarchy to produce coherent memory-guided cognition. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://researchonline.ljmu.ac.uk/id/eprint/23441/7/A%20double%20dissociation%20between%20semantic%20and%20spatial%20cognition%20in%20visual%20to%20default%20network%20pathways.pdf; Gonzalez Alam, TRJ ORCID logoorcid:0000-0003-4510-2441 , Krieger-Redwood, K ORCID logoorcid:0000-0003-4143-1168 , Varga, D ORCID logoorcid:0000-0002-5851-0498 , Gao, Z ORCID logoorcid:0000-0002-8909-8096 , Horner, A ORCID logoorcid:0000-0003-0882-9756 , Hartley, T ORCID logoorcid:0000-0002-4072-6637 , Thiebaut de Schotten, M ORCID logoorcid:0000-0002-0329-1814 , Sliwinska, MW ORCID logoorcid:0000-0002-5211-0311 , Pitcher, D ORCID logoorcid:0000-0001-8526-2111 , Margulies, DS ORCID logoorcid:0000-0002-8880-9204 , Smallwood, J ORCID logoorcid:0000-0002-7298-2459 and Jefferies, E ORCID logoorcid:0000-0002-3826-4330 (2025) A double dissociation between semantic and spatial cognition in visual to default network pathways. eLife - Neuroscience, 13. pp. 1-35. |
| DOI: |
10.7554/eLife.94902.3 |
| Availability: |
https://researchonline.ljmu.ac.uk/id/eprint/23441/; https://researchonline.ljmu.ac.uk/id/eprint/23441/7/A%20double%20dissociation%20between%20semantic%20and%20spatial%20cognition%20in%20visual%20to%20default%20network%20pathways.pdf; https://doi.org/10.7554/eLife.94902.3 |
| Rights: |
cc_by |
| Accession Number: |
edsbas.29821DF |
| Database: |
BASE |