| Title: |
Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients |
| Authors: |
Stemler, J.; Bruns, C.; Mellinghoff, S.C.; Alakel, N.; Akan, H.; Ananda-Rajah, M.; Auberger, J.; Bojko, P.; Chandrasekar, P.H.; Chayakulkeeree, M.; Cozzi, J.A.; Kort, E.A. de; Groll, A.H.; Heath, C.H.; Henze, L.; Hernandez Jimenez, M.; Kanj, S.S.; Khanna, N.; Koldehoff, M.; Lee, D.G.; Mager, A.; Marchesi, F.; Martino-Bufarull, R.; Nucci, M.; Oksi, J.; Pagano, L.; Phillips, B.; Prattes, J.; Pyrpasopoulou, A.; Rabitsch, W.; Schalk, E.; Schmidt-Hieber, M.; Sidharthan, N.; Soler-Palacin, P.; Stern, A.; Weinbergerova, B.; El Zakhem, A.; Cornely, O.A.; Koehler, P. |
| Source: |
Journal of Fungi, 6, 1 ; https://res.mdpi.com/d_attachment/jof/jof-06-00036/article_deploy/jof-06-00036.pdf |
| Publication Year: |
2020 |
| Collection: |
Radboud University: DSpace |
| Subject Terms: |
Radboudumc 2: Cancer development and immune defence RIHS: Radboud Institute for Health Sciences; Haematology - Radboud University Medical Center |
| Description: |
Contains fulltext : 218254.pdf (Publisher’s version ) (Open Access) ; Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://repository.ubn.ru.nl//bitstream/handle/2066/218254/218254.pdf; https://hdl.handle.net/2066/218254 |
| DOI: |
10.3390/jof6010036 |
| Availability: |
https://hdl.handle.net/2066/218254; https://repository.ubn.ru.nl//bitstream/handle/2066/218254/218254.pdf; https://doi.org/10.3390/jof6010036 |
| Accession Number: |
edsbas.2989E6AF |
| Database: |
BASE |