| Title: |
Survival and modelled cancer antigen-125 ELIMination rate constant K score in ovarian cancer patients in first-line before poly(ADP-ribose) polymerase inhibitor era: A Gynaecologic Cancer Intergroup meta-analysis |
| Authors: |
Corbaux, Pauline; You, Benoit; Glasspool, Rosalind M.; Yanaihara, Nozomu; Tinker, Anna V.; Lindemann, Kristina; Ray-Coquard, Isabelle Laure; Mirza, Mansoor Raza; Subtil, Fabien; Colomban, Olivier; Péron, Julien; Karamouza, Eleni; Mcneish, Iain A.; Kelly, Caroline A.; Kagimura, Tatsuo; Welch, Stephen A.; Lewsley, Liz Anne; Paoletti, Xavier; Cook, Adrian D. |
| Contributors: |
Centre pour l'innovation en cancérologie de Lyon (CICLY); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon; Centre Léon Bérard Lyon; Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE); Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Institut Curie Paris; Groupe d'Investigateurs National des Etudes des Cancers Ovariens et du sein; Gynaecologic Cancer Intergroup; University Claude Bernard; Hospices Civils de Lyon, HCL |
| Source: |
ISSN: 0959-8049 ; European Journal of Cancer ; https://hal.science/hal-04229567 ; European Journal of Cancer, 2023, 191, ⟨10.1016/j.ejca.2023.112966⟩. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2023 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
CA-125; KELIM; Ovarian cancer; Primary chemosensitivity; Prognostic biomarker; Surrogate end-point; [SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: |
International audience ; Background: In patients with advanced ovarian cancer, the modelled CA-125 ELIMination rate constant K (KELIM) is an early indicator of the tumour intrinsic chemosensitivity. We assessed the prognostic and surrogate values of KELIM with respect to those of surgery outcome (based on post-operative residual lesions) in the Gynaecologic Cancer Intergroup (GCIG) individual patient data meta-analysis MAOV (Meta-Analysis in OVarian cancer) built before the emergence of poly(ADP-ribose) polymerase (PARP) inhibitors. Methods: The dataset was split into learning and validation cohorts (ratio 1:2). The individual modelled KELIM values were estimated, standardised by the median value, then scored as unfavourable ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37542936; PUBMED: 37542936 |
| DOI: |
10.1016/j.ejca.2023.112966 |
| Availability: |
https://hal.science/hal-04229567; https://hal.science/hal-04229567v1/document; https://hal.science/hal-04229567v1/file/1-s2.0-S0959804923003180-main.pdf; https://doi.org/10.1016/j.ejca.2023.112966 |
| Rights: |
http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.29A9E11D |
| Database: |
BASE |