| Title: |
A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Study |
| Authors: |
Karahan, Ali Yavuz; Yalin, Ozgur Osman; Baybas, Sevim; Colakoglu, Sena; Domac, Fusun Mayda; Ince, Birsen; Aluclu, Ufuk; NAZLIEL, BİJEN; Misirli, Cemile Handan; Cinar, Nilgun; Demirci, Seden; Senol, Mehmet Guney; Caglayan, Hale Zeynep Batur; Zeydan, Burcu; YAMAN, MEHMET; ÖZTÜRK, ŞEREFNUR; Goksan, Baki; KOZAK, HASAN HÜSEYİN; UZUNER, Nevzat; Yayla, Vildan; Goksu, Eylem Ozaydin; Utku, Uygar; Tufekci, Ahmet; Orken, Dilek Necioglu; Yilmaz, Arda; Milanlıoğlu, Aysel; Bektas, Hesna; Genc, Hamit; Oruc, Serdar; Uluduz, Derya; Ekmekci, Hakan; MİDİ, İPEK; Cabalar, Murat; Kucukoglu, Hayriye; KABLAN, YÜKSEL; GÖKÇE, MUSTAFA; Mengulluoglu, Necdet; Goksel, Basak K.; Ozdag, Fatih; Yesilot, Nilufer; YÜREKLİ, Vedat Ali; Tokuc, Firdevs Ezgi Ucan; Afsar, Nazire; Aytac, Emrah; Uzuner, Gulnur; Tascilar, Nida; Bakar, Mustafa; Kuspeci, Ozge Yilmaz; Demir, Serkan; Tekeli, Hakan; Acikgoz, Mustafa; Duman, Taskin |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2025 |
| Subject Terms: |
Adult; Male; Adolescent; Risk Assessment; Imaging; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Risk Factors; Seizures; Prevalence; Humans; Prospective Studies; erebral venous sinus thrombosis; clinic; Cerebrovascular disease; Blood Coagulation; Retrospective Studies; Incidence; Age Factors; Headache; Middle Aged; Prognosis; 3. Good health; Pregnancy Complications; Female; Intracranial Thrombosis; cerebral venous sinus thrombosis |
| Time: |
610; 616 |
| Description: |
Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients.All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution.Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis.Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
Journal of Stroke and Cerebrovascular Diseases; https://hdl.handle.net/20.500.12628/23952; 000407019200036; 1848; 1857; 26 |
| DOI: |
10.1016/j.jstrokecerebrovasdis.2017.04.020 |
| Availability: |
https://hdl.handle.net/20.500.12628/23952; https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.04.020 |
| Rights: |
OPEN |
| Accession Number: |
edsbas.29AEB687 |
| Database: |
BASE |