| Title: |
selected oral and vaginal Candida pathogens |
| Authors: |
Short Communication; Parveen Surain; Kamal Rai Aneja |
| Contributors: |
The Pennsylvania State University CiteSeerX Archives |
| Source: |
http://jibresearch.com/Manuscript PDF/Manuscript JIB-201402-008.pdf. |
| Publication Year: |
2014 |
| Collection: |
CiteSeerX |
| Subject Terms: |
Crinum asiaticum; MIC; Candida; candidiasis; Inhibition; Characterization |
| Description: |
Discovery of active principles in plants have given credence to the idea that integration of traditional medicine into the health care delivery would be very promising and should be encouraged. The incidence of Candida infections are rising at an alarming rate throughout the world. To overcome these alarming problem researchers are increasingly turning their attention to folk medicine, looking for new leads to develop better drugs against microbial infections. Different organic and aqueous extracts of Crinum asiaticum were screened for their anticandidal activity against five (9 isolates) human pathogenic Candida spp. by agar well diffusion assay. The pattern of growth inhibition varied with the six different solvents used for extraction. Out of six solvents, dichloromethane showed best activity against all tested Candida spp. with zone of inhibition ranging between 12.3mm and 20.6mm. Of the five Candida spp., C.albicans strain-2 was found to be most sensitive with maximum zone of inhibition of 20.6mm followed by C.krusei strain-1(17.3mm), C.albicans strain-4, C.glabrata (15.6mm) , C.albicans strain-1 (14.6), C.albicans strain-3 (12.3mm) and no activity was observed in C.tropicalis, C.krusei strain-2 and C.lusitaniae. The MIC tested for all the leaves extracts ranged between 100mg/ml and 6.25 mg/ml in dichloromethane extract. The result obtained in the present study suggests that the dichloromethane extract of C.asiaticum can be used in treating candidiasis caused by different species of Candida. however, further investigations will be needed for the isolation, characterization and exploitation of bioactive principles responsible for anticandidal activity. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.428.5574 |
| Availability: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.428.5574; http://jibresearch.com/Manuscript PDF/Manuscript JIB-201402-008.pdf |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: |
edsbas.29FB155F |
| Database: |
BASE |