| Title: |
Homogeneity of pathological response (PR) and histopathological growth pattern (HGP) in resected colorectal liver metastases (CRLM) are associated with favorable survival outcome after surgery. |
| Authors: |
Baldin, Paméla; Beniuga, Gabriella; Carrasco, Javier; De Cuyper, Astrid; Sinapi, Isabelle; Hubert, Catherine; Navez, Benoît; Castella, Marie-Laure; Van Maanen, Aline; Mlecnik, Bernhard; Galon, Jerome; Jouret-Mourin, Anna; Van den Eynde, Marc; 2022 ASCO Annual Meeting I |
| Contributors: |
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie; UCL - (SLuc) Service d'hépato-gastro-entérologie; UCL - (SLuc) Service d'oncologie médicale; UCL - (SLuc) Service d'anatomie pathologique |
| Source: |
Journal of Clinical Oncology, Vol. 40, no.16_suppl, p. 3596-3596 (2022) |
| Publisher Information: |
American Society of Clinical Oncology (ASCO) |
| Publication Year: |
2022 |
| Collection: |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| Subject Terms: |
Cancer Research; Oncology |
| Description: |
Background: Surgical resection of CRLM aims to maximize patient survival. However, recurrence rates remain high post-surgery. We previously reported the prognostic relevance of tumor regression grading (TRG) and HGP of resected CRLM. Several studies reported the association of tumoral heterogeneity with anti-cancer drug resistance and prognosis. This study aims to explore tumoral heterogeneity for TRG and HGP in patients resected for CRLM and its prognostic implication. Methods: Tumor homogeneity for PR and HGP was evaluated in 2 independent cohorts. Cohort 1 included 57 patients (159 CRLMs) resected after chemotherapy/bevacizumab (prospective BEV-ONCO trial). Cohort 2 included 221 patients (582 CRLMs) operated after preoperative treatment or not. TRG (1 to 5 according complete to no response), HGP (desmoplastic, pushing, replacement or mixed) were evaluated for each CRLM. Max-TRG (higher TRG among all the CRLM) was used to define PR. Homogenous TRG (TRG-h) and HGP (HGP-h) was defined when all CRLMs had the same TRG or HGP pattern. HGP homogeneous desmoplastic (HGP-hd) was defined when all CRLM had a desmoplastic HGP. TRG-h, HGP-h and HGP-hd were combined into a homogeneity score (H-score: 0 to 3, 1 point given for each parameter and summed-up). Overall survival (OS for both cohorts), progression-free survival (PFS for cohort 1) and time to relapse (TTR for cohort 2) were estimated using the Kaplan–Meier method and compared by log-rank tests. Cox proportional hazard models were used for univariate and multivariate analyses. Results: Patient and disease characteristics were comparable in both cohorts excepted for preoperative treatment. In cohort 1, TRG-h and HGP-h were significantly associated with a longer PFS (HR = 0.21; 95CI:0.10-0.43, p < 0.001; HR = 0.27; 95CI = 0.14-0.54, p < 0.001) and better OS (HR = 0.23; 95CI = 0.07-0.70, p = 0.010; HR = 0.32; 95CI = 0.10-0.93, p = 0.037). Interestingly, the same significant results were observed in cohort 2 for TTR (TRG-h: HR = 0.60; 95CI = 0.43-0.85, p = 0.004; ... |
| Document Type: |
conference object |
| Language: |
English |
| Relation: |
boreal:277921; http://hdl.handle.net/2078.1/277921 |
| DOI: |
10.1200/jco.2022.40.16_suppl.3596 |
| Availability: |
http://hdl.handle.net/2078.1/277921; https://doi.org/10.1200/jco.2022.40.16_suppl.3596 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.2A2BE72C |
| Database: |
BASE |