| Title: |
High-throughput characterization of bacterial responses to complex mixtures of chemical pollutants |
| Authors: |
Smith, TP; Clegg, T; Ransome, E; Martin-Lilley, T; Rosindell, J; Woodward, G; Pawar, S; Bell, T |
| Source: |
948 ; 938 |
| Publisher Information: |
Nature Research |
| Publication Year: |
2024 |
| Collection: |
Imperial College London: Spiral |
| Subject Geographic: |
England |
| Description: |
Our understanding of how microbes respond to micropollutants, such as pesticides, is almost wholly based on single-species responses to individual chemicals. However, in natural environments, microbes experience multiple pollutants simultaneously. Here we perform a matrix of multi-stressor experiments by assaying the growth of model and non-model strains of bacteria in all 255 combinations of 8 chemical stressors (antibiotics, herbicides, fungicides and pesticides). We found that bacterial strains responded in different ways to stressor mixtures, which could not be predicted simply from their phylogenetic relatedness. Increasingly complex chemical mixtures were both more likely to negatively impact bacterial growth in monoculture and more likely to reveal net interactive effects. A mixed co-culture of strains proved more resilient to increasingly complex mixtures and revealed fewer interactions in the growth response. These results show predictability in microbial population responses to chemical stressors and could increase the utility of next-generation eco-toxicological assays. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Nature Microbiology; http://hdl.handle.net/10044/1/110907 |
| DOI: |
10.1038/s41564-024-01626-9 |
| Availability: |
http://hdl.handle.net/10044/1/110907; https://doi.org/10.1038/s41564-024-01626-9 |
| Rights: |
© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.2A2DCF57 |
| Database: |
BASE |