| Title: |
Multicenter Randomized Trial of Methylprednisolone vs. Intravenous Immunoglobulins to Treat the Pediatric Inflammatory Multisystem Syndrome-Temporally Associated With SARS-CoV-2 (PIMS-TS): Protocol of the Swissped RECOVERY Trial |
| Authors: |
Welzel, Tatjana; Schöbi, Nina; André, Maya C; Bailey, Douggl G N; Blanchard-Rohner, Geraldine; Buettcher, Michael; Grazioli, Serge; Koehler, Henrik; Perez, Marie-Helene; Trück, Johannes; Vanoni, Federica; Zimmermann, Petra; Atkinson, Andrew; Sanchez, Carlos; Whittaker, Elizabeth; Faust, Saul N; Bielicki, Julia A; Schlapbach, Luregn J |
| Publication Year: |
2022 |
| Collection: |
University of Southampton: e-Prints Soton |
| Description: |
Introduction: In 2020, a new disease entitled Pediatric Inflammatory Multisystem Syndrome temporally associated with COVID-19 (PIMS-TS), or Multisystem Inflammatory Syndrome in Children (MIS-C), emerged, with thousands of children affected globally. There is no available evidence based on randomized controlled trials (RCT) to date on the two most commonly used immunomodulatory treatments, intravenous immunoglobulins (IVIG) and corticosteroids. Therefore, the Swissped RECOVERY trial was conducted to assess whether intravenous (IV) methylprednisolone shortens hospital length of stay compared with IVIG. Methods and Analysis: Swissped RECOVERY is an ongoing investigator-initiated, open-label, multicenter two-arm RCT in children and adolescents |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.soton.ac.uk/467970/1/fped_10_905046_2_.pdf; Welzel, Tatjana, Schöbi, Nina, André, Maya C, Bailey, Douggl G N, Blanchard-Rohner, Geraldine and Buettcher, Michael , Swissped Recovery Trial and et al. (2022) Multicenter Randomized Trial of Methylprednisolone vs. Intravenous Immunoglobulins to Treat the Pediatric Inflammatory Multisystem Syndrome-Temporally Associated With SARS-CoV-2 (PIMS-TS): Protocol of the Swissped RECOVERY Trial. Frontiers in Pediatrics, 10, [905046]. (doi:10.3389/fped.2022.905046 ). |
| Availability: |
https://eprints.soton.ac.uk/467970/; https://eprints.soton.ac.uk/467970/1/fped_10_905046_2_.pdf |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.2A9B70D |
| Database: |
BASE |