| Title: |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals |
| Authors: |
Lee, J.; Wedow, R.; Okbay, A.; Kong, E.; Maghzian, O.; Zacher, M.; Nguyen-Viet, T.; Bowers, P.; Sidorenko, J.; Linnér, R.; Fontana, M.; Kundu, T.; Lee, C.; Li, H.; Li, R.; Royer, R.; Timshel, P.; Walters, R.; Willoughby, E.; Yengo, L.; Social Science Genetic Association Consortium; Alver, M.; Bao, Y.; Clark, D.; Day, F.; Furlotte, N.; Joshi, P.; Kemper, K.; Kleinman, A.; Langenberg, C.; Mägi, R.; Trampush, J.; Verma, S.; Wu, Y.; Lam, M.; Zhao, J.; Zheng, Z.; Boardman, J.; Campbell, H.; Freese, J.; Harris, K.; Hayward, C.; Herd, P.; Kumari, M.; Lencz, T.; Luan, J.; Malhotra, A.; Metspalu, A.; Milani, L.; Ong, K.; Perry, J.; Porteous, D.; Ritchie, M.; Smart, M.; Smith, B.; Tung, J.; Wareham, N.; Wilson, J.; Beauchamp, J.; Conley, D.; Esko, T.; Lehrer, S.; Magnusson, P.; Oskarsson, S.; Pers, T.; Robinson, M.; Thom, K.; Watson, C.; Chabris, C.; Meyer, M.; Laibson, D.; Yang, J.; Johannesson, M.; Koellinger, P.; Turley, P.; Visscher, P.; Benjamin, D.; Cesarini, D. |
| Contributors: |
23andMe Research Team; COGENT (Cognitive Genomics Consortium) |
| Source: |
Nature Genetics |
| Publication Year: |
2018 |
| Collection: |
Max Planck Society: MPG.PuRe |
| Description: |
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Availability: |
http://hdl.handle.net/21.11116/0000-0002-AF23-2; http://hdl.handle.net/21.11116/0000-0002-AF25-0 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.2AE2F76B |
| Database: |
BASE |