Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment
| Title: | Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment |
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| Authors: | Justin A. Spanier; Daniel R. Frederick; Justin J. Taylor; James R. Heffernan; Dmitri I. Kotov; Tijana Martinov; Kevin C. Osum; Jenna L. Ruggiero; Blake J. Rust; Samuel J. Landry; Marc K. Jenkins; James B. McLachlan; Brian T. Fife |
| Source: | Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
| Publisher Information: | Nature Portfolio |
| Publication Year: | 2016 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | Science |
| Description: | Generating antibodies specific for the peptide–MHCII complexes has been challenging, with only a handful made to date. Here, the authors develop a more efficient approach to generate these antibodies, and demonstrate their potential in research and therapeutic applications. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://doi.org/10.1038/ncomms11804; https://doaj.org/toc/2041-1723; https://doaj.org/article/8c2e27eaab1b4cc89a8d7d85fe9db231 |
| DOI: | 10.1038/ncomms11804 |
| Availability: | https://doi.org/10.1038/ncomms11804; https://doaj.org/article/8c2e27eaab1b4cc89a8d7d85fe9db231 |
| Accession Number: | edsbas.2AF68E80 |
| Database: | BASE |