| Title: |
Household Transmission of the 2009 Pandemic A/H1N1 Influenza Virus: Elevated Laboratory-Confirmed Secondary Attack Rates and Evidence of Asymptomatic Infections |
| Authors: |
Papenburg, Jesse; Baz, Mariana; Hamelin, Marie-Ève; Rhéaume, Chantal; Carbonneau, Julie; Ouakki, Manale; Rouleau, Isabelle; Hardy, Isabelle; Skowronski, Danuta; Roger, Michel; Charest, Hugues; Serres, Gaston De; Boivin, Guy |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2010 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Major Articles |
| Description: |
Background. Characterizing household transmission of the 2009 pandemic A/H1N1 influenza virus (pH1N1) is critical for the design of effective public health measures to mitigate spread. Our objectives were to estimate the secondary attack rates (SARs), the proportion of asymptomatic infections, and risk factors for pH1N1 transmission within households on the basis of active clinical follow-up and laboratory-confirmed outcomes. Methods. We conducted a prospective observational study during the period May-July 2009 (ie, during the first wave of the pH1N1 pandemic) in Quebec City, Canada. We assessed pH1N1 transmission in 42 households (including 43 primary case patients and 119 contacts). Clinical data were prospectively collected during serial household visits. Secondary case patients were identified by clinical criteria and laboratory diagnostic tests, including serological and molecular methods. Results. We identified 53 laboratory-confirmed secondary case patients with pH1N1 virus infection, for an SAR of 45% (95% confidence interval [CI], 35.6%–53.5%). Thirty-four (81%) of the households had ∼1 confirmed secondary case patient. The mean serial interval between onset of primary and confirmed secondary cases was 3.9 days (median interval, 3 days). Influenza-like illness (fever and cough or sore throat) developed in 29% (95% CI, 20.5%–36.7%) of household contacts. Five (9.4%) of secondary case patients were asymptomatic. Young children ( |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://cid.oxfordjournals.org/cgi/content/short/51/9/1033; http://dx.doi.org/10.1086/656582 |
| DOI: |
10.1086/656582 |
| Availability: |
http://cid.oxfordjournals.org/cgi/content/short/51/9/1033; https://doi.org/10.1086/656582 |
| Rights: |
Copyright (C) 2010, Infectious Diseases Society of America |
| Accession Number: |
edsbas.2B3DDC5C |
| Database: |
BASE |