| Title: |
Impact of CTO Revascularization on Sudden Cardiac Death and/or Ventricular Arrhythmias: A Meta-Analysis of Observational Studies |
| Authors: |
Sfairopoulos, Dimitrios; Bazoukis, George; Liu, Haipeng; Saplaouras, Athanasios; Efthymiou, Polyxeni; Yiannikourides, Andronicos; Pagkalidou, Eirini; Liu, Tong; Korantzopoulos, Panagiotis; Letsas, Konstantinos P; Efremidis, Michael; Tse, Gary; Brilakis, Emmanouil S |
| Source: |
Current Cardiology Reviews ; volume 22 ; ISSN 1573-403X |
| Publisher Information: |
Bentham Science Publishers Ltd. |
| Publication Year: |
2026 |
| Description: |
Introduction: The presence of a chronic total occlusion (CTO) has been associated with increased risk of sudden cardiac death (SCD) and/or ventricular arrhythmias (VAs). This study aimed to evaluate the impact of CTO revascularization on SCD and/or VAs. Methods: A systematic review of the literature was performed to identify studies evaluating the association between CTO revascularization and risk of SCD and/or VAs. Results: Six studies were included in the final meta-analysis. The total sample size included 2,017 participants for the assessment of the primary outcome of interest and 868 participants for the assessment of the secondary outcome of interest. In 5 studies examining the association between CTO revascularization and risk of SCD and/or VAs, CTO revascularization was not associated with a statistically significant reduction in the risk of SCD and/or VAs (HR: 0.78; 95% CI: 0.38 to 1.60; p = 0.50, I2 = 87%). Conversely, in 2 studies examining the association between IRA-CTO revascularization and risk of SCD and/or VAs, IRA-CTO revascularization was associated with 79% lower risk of SCD and/or VAs (HR: 0.21; 95% CI: 0.10 to 0.43; p < 0.0001, I2 = 0%). Discussion: CTO revascularization overall was not associated with a lower risk of SCD and/or VAs. In contrast, IRA-CTO revascularization was associated with a lower risk of SCD and/or VAs. However, the study has several limitations, primarily due to the observational nature of the included studies. Conclusion: Successful revascularization of an IRA-CTO should be attempted to reduce the burden of VAs and reduce the risk of SCD. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.2174/011573403x393707251009072715 |
| DOI: |
10.2174/011573403X393707251009072715 |
| Availability: |
https://doi.org/10.2174/011573403x393707251009072715; https://www.eurekaselect.com/article/download?doi=10.2174/011573403X393707251009072715; https://www.eurekaselect.com/251074/article |
| Accession Number: |
edsbas.2B51FDA7 |
| Database: |
BASE |