| Title: |
Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) : an open-label, multicentre, randomised trial |
| Authors: |
Welzel, Tatjana; Atkinson, Andrew; Schöbi, Nina; Andre, Maya C; Bailey, Douggl G N; Blanchard Rohner, Géraldine; Buettcher, Michael; Grazioli, Serge; Koehler, Henrik; Perez, Marie-Helene; Trück, Johannes; Vanoni, Federica; Zimmermann, Petra; Sanchez, Carlos; Bielicki, Julia A; Schlapbach, Luregn J; Swissped RECOVERY Trial Group |
| Contributors: |
Polito, Angelo; Wagner, Noémie; L'Huillier, Arnaud; Bordessoule, Alice-Charlotte; Martin, Anne-Laure; Rohr, Marie Madeleine; Hofer, Michael |
| Source: |
ISSN: 2352-4642 ; The Lancet. Child & adolescent health, vol. 7, no. 4 (2023) p. 238-248. |
| Publication Year: |
2023 |
| Collection: |
Université de Genève: Archive ouverte UNIGE |
| Subject Terms: |
info:eu-repo/classification/ddc/618; Humans; Child; Adolescent; COVID-19; SARS-CoV-2; Immunoglobulins; Intravenous / therapeutic use; Methylprednisolone / therapeutic use; Randomized Controlled Trials as Topic |
| Description: |
Background: The emergence of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) led to the widespread use of anti-inflammatory treatments in the absence of evidence from randomised controlled trials (RCTs). We aimed to assess the effectiveness of intravenous methylprednisolone compared with intravenous immunoglobulins. Methods: This is an open-label, multicentre, two-arm RCT done at ten hospitals in Switzerland in children younger than 18 years hospitalised with PIMS-TS (defined as age |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36746174; unige:180898 |
| Availability: |
https://archive-ouverte.unige.ch/unige:180898 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.2B5A0C9B |
| Database: |
BASE |