Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation
| Title: | Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation |
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| Authors: | Daynes E; Evans RA; Greening NJ; Bishop NC; Yates T; Lozano-Rojas D; Ntotsis K; Richardson M; Baldwin MM; Hamrouni M; Hume E; McAuley H; Mills G; Megaritis D; Roberts M; Bolton CE; Chalmers JD; Chalder T; Docherty AB; Elneima O; Harrison EM; Harris VC; Ho LP; Horsley A; Houchen-Wolloff L; Leavy OC; Marks M; Poinasamy K; Quint JK; Raman B; Saunders RM; Shikotra A; Singapuri A; Sereno M; Terry S; Wain LV; Man WD-C; Echevarria C; Vogiatzis I; Brightling C; Singh SJ |
| Source: | European Respiratory Journal, 2025 |
| Publisher Information: | European Respiratory Society |
| Publication Year: | 2025 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | Copyright ©The authors 2025. Objective: Post-COVID syndrome involves prolonged symptoms with multisystem and functional impairment lasting ≽12 weeks after acute coronavirus disease 2019 (COVID-19). We aimed to determine the efficacy of exercise-based rehabilitation interventions, either face-to-face or remote, compared to usual care in individuals experiencing post-COVID syndrome following a hospitalisation with acute COVID-19. Design: This single-blind randomised controlled trial compared two exercise-based rehabilitation interventions (face-to-face or remote) to usual care in participants with post-COVID syndrome following a hospitalisation. The interventions were either a face-to-face or remote 8-week programme of individually prescribed exercise and education. The primary outcome was the change in Incremental Shuttle Walking Test (ISWT) following 8 weeks of intervention (either face-to-face or remote) compared to usual care. Other secondary outcomes were measured including health-related quality of life (HRQoL), and exploratory outcomes included lymphocyte immunotyping. Results: 181 participants (55% male, mean±SD age 59±12 years, length of hospital stay 12±19 days) were randomised. There was an improvement in the ISWT distance following face-to-face rehabilitation (mean 52 m, 95% CI 19–85 m; p=0.002) and remote rehabilitation (mean 34 m, 95% CI 1–66 m; p=0.047) compared to usual care alone. There were no differences between groups for HRQoL self-reported symptoms. Analysis of immune markers revealed significant increases in naïve and memory CD8+ T-cells following face-to-face rehabilitation versus usual care alone (p |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/306307; https://eprints.ncl.ac.uk/fulltext.aspx?url=306307/F0B3626E-97A9-4D20-9992-A68DC44EB7E2.pdf&pub_id=306307 |
| Availability: | https://eprints.ncl.ac.uk/306307 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.2B6F49E6 |
| Database: | BASE |