| Title: |
Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis |
| Authors: |
Tsimpiris, Athanasios; Tsolianos, Ioannis; Grigoriadis, Andreas; Moschos, Ioannis; Goulis, Dimitrios G.; Kouklakis, Georgios |
| Source: |
European Journal of Dentistry ; volume 17, issue 02, page 270-282 ; ISSN 1305-7456 1305-7464 |
| Publisher Information: |
Georg Thieme Verlag KG |
| Publication Year: |
2022 |
| Description: |
Helicobacter pylori (H. pylori) infection and periodontitis are both inflammatory conditions associated with systemic diseases. Researchers have attempted to investigate the correlation between them. This systematic review and meta-analyses were conducted to investigate the association of H. pylori infection in the stomach and/or in subgingival plaque and gingival crevicular fluid with chronic periodontitis. The protocol was created according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. The study was designed according to the Cochrane criteria. A comprehensive literature search was performed in MEDLINE, Scopus, and CENTRAL, combined with hand-searching and assessment of gray literature. The meta-analysis of the included studies was made by the Review Manager (RevMan) 5.4 software. The effect measure of the outcome was odds ratios with 95% confidence intervals. Heterogeneity was assessed by chi-square and I2. Four observational studies involving 818 subjects were included in this meta-analysis. The odds of oral H. pylori presence were higher in patients with chronic periodontitis, compared to healthy controls, with an odds ratio of 1.87 (95% confidence interval 0.85–4.10; p = 0.12). The odds of the presence of H. pylori in the stomach also were higher in patients with chronic periodontitis, with an odds ratio of 1.80 (95% confidence interval 0.82–3.95; p = 0.15). There is no evidence for an association between chronic periodontitis and the prevalence of H. pylori, detected either in subgingival plaque and gingival crevicular fluid or in the stomach. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1055/s-0042-1756690 |
| DOI: |
10.1055/s-0042-1756690.pdf |
| Availability: |
https://doi.org/10.1055/s-0042-1756690; http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1756690.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.2B6F6142 |
| Database: |
BASE |