| Title: |
Synthesis, reactivity, and antimicrobial properties of boron-containing 4-ethyl-3-thiosemicarbazide derivatives |
| Authors: |
Scott, Ryan S.; Veinot, Alex J.; Stack, Darcie L.; Gormley, Patrick T.; Khuong, B. Ninh; Vogels, Christopher M.; Masuda, Jason D.; Baerlocher, Felix J.; MacCormack, Tyson J.; Westcott, Stephen A. |
| Source: |
Canadian Journal of Chemistry ; volume 96, issue 10, page 906-911 ; ISSN 0008-4042 1480-3291 |
| Publisher Information: |
Canadian Science Publishing |
| Publication Year: |
2018 |
| Description: |
The addition of 4-ethyl-3-thiosemicarbazide to benzaldehyde and boronic acid containing derivatives afforded the corresponding thiosemicarbazones (1–3) or benzodiazaborines (4–6) depending on the position of the boronic acid within the ring. All compounds have been characterized fully including an X-ray diffraction study of the methoxy-containing benzodiazaborine 6. Attempts to coordinate thiosemicarbazones 2 and 3 to palladium(II) acetate were unsuccessful; however, addition of the non-boron-containing derivative 1 to palladium afforded complex 7 whose molecular structure was determined by an X-ray diffraction study. The initial bioactivities of compounds 1–7 were examined against two fungi, Aspergillus niger and Saccharomyces cerevisiae, and two bacteria, Bacillus cereus and Pseudomonas aeruginosa. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1139/cjc-2018-0108 |
| Availability: |
https://doi.org/10.1139/cjc-2018-0108; https://cdnsciencepub.com/doi/full-xml/10.1139/cjc-2018-0108; https://cdnsciencepub.com/doi/pdf/10.1139/cjc-2018-0108 |
| Rights: |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
| Accession Number: |
edsbas.2B9F9249 |
| Database: |
BASE |