A living WHO guideline on drugs to prevent covid-19
| Title: | A living WHO guideline on drugs to prevent covid-19 |
|---|---|
| Authors: | Lamontagne F; Agoritsas T; Siemieniuk R; Rochwerg B; Bartoszko J; Askie L; Macdonald H; Amin W; Bausch FJ; Burhan E; Cecconi M; Chanda D; Dat VQ; Du B; Geduld H; Gee P; Nerina H; Hashimi M; Hunt BJ; Kabra S; Kanda S; Kawano-Dourado L; Kim Y-J; Kissoon N; Kwizera A; Leo Y-S; Mahaka I; Manai H; Mino G; Nsutebu E; Pshenichnaya N; Qadir N; Ranganathan SS; Sabzwari S; Sarin R; Sharland M; Shen Y; Souza JP; Stegemann M; Ugarte S; Venkatapuram S; Vuyiseka D; Preller J; Brignardello-Petersen R; Kum E; Qasim A; Zeraatkar D; Owen A; Guyatt G; Lytvyn L; Diaz J; Vandvik PO; Jacobs M |
| Publisher Information: | BMJ |
| Publication Year: | 2021 |
| Collection: | McMaster University: MacSphere |
| Subject Terms: | COVID-19; Chemoprevention; Clinical Decision-Making; Humans; Hydroxychloroquine; Immunologic Factors; Risk Assessment; SARS-CoV-2; Uncertainty; World Health Organization |
| Description: | Abstract Clinical question What is the role of drugs in preventing covid-19? Why does this matter? There is widespread interest in whether drug interventions can be used for the prevention of covid-19, but there is uncertainty about which drugs, if any, are effective. The first version of this living guideline focuses on the evidence for hydroxychloroquine. Subsequent updates will cover other drugs being investigated for their role in the prevention of covid-19. Recommendation The guideline development panel made a strong recommendation against the use of hydroxychloroquine for individuals who do not have covid-19 (high certainty). How this guideline was created This living guideline is from the World Health Organization (WHO) and provides up to date covid-19 guidance to inform policy and practice worldwide. Magic Evidence Ecosystem Foundation (MAGIC) provided methodological support. A living systematic review with network analysis informed the recommendations. An international guideline development panel of content experts, clinicians, patients, an ethicist and methodologists produced recommendations following standards for trustworthy guideline development using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Understanding the new recommendation The linked systematic review and network meta-analysis (6 trials and 6059 participants) found that hydroxychloroquine had a small or no effect on mortality and admission to hospital (high certainty evidence). There was a small or ... |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://hdl.handle.net/11375/26590; https://doi.org/10.1136/bmj.n526 |
| DOI: | 10.1136/bmj.n526 |
| Availability: | https://hdl.handle.net/11375/26590; https://doi.org/10.1136/bmj.n526 |
| Accession Number: | edsbas.2BAC3A4E |
| Database: | BASE |