| Title: |
Prostate cancer clinicopathological presentation in South-East Africa during the 2010 decade |
| Authors: |
Patrick, Sean M; Ombuki, Winstar Mokua; Ndambuki, Joan; Oyaro, Micah O; Bida, Meshack; Soh, Pamela X Y; Prins, Gail S; Argos, Maria; Barnhoorn, Irene; Brewer, Daniel S; Campbell, Raymond; Craddock, Jenna; Eeles, Rosalind A; Jaratlerdsiri, Weerachai; Lebelo, Maphuti Tebogo; Loda, Massimo; Louw, Melanie; Lutsik, Pavlo; Madueke, Ikenna C; Mbeke, Tumisang M N; Moreira, Daniel M; Mutambirwa, Shingai B A; Nyaga, Muriuki Elias; Obida, Martin; Obida, Muvhulawa; Oyieko, Willis; Radzuma, Mulalo B; Shirinde, Joyce; Walker, Douglas I; Walong, Edwin O O; Wanjiku, Githui Sheila; Wedge, David C; Yienya, Allan; Hayes, Vanessa M; Bornman, M S Riana; Ngugi, Peter Mungai |
| Contributors: |
Congressionally Directed Medical Research Program; DoD Prostate Cancer Research Program; Health Equity Research and Outcomes Improvement Consortium; HEROIC PCaPH Africa1K Consortium; National Institute of Health; National Cancer Institute; Prostate Cancer Foundation; Cancer Association of South Africa; University of Sydney Foundation |
| Source: |
JNCI: Journal of the National Cancer Institute ; volume 117, issue 12, page 2677-2681 ; ISSN 0027-8874 1460-2105 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Prostate cancer is the leading cause of cancer-associated death among men across Sub-Saharan Africa, with Southern and East Africa ranking first and fifth globally. However, lack of coordinated national cancer registries has biased data toward single-sourced, averaged, or model estimates. Here, our retrospective study included 8634 South-East African patients diagnosed between 2010 and 2019, which when compared with 71 694 Black and 322 356 White period-matched American men, were over threefold more likely to present with aggressive disease (International Society of Urological Pathology grade groups ≥4: 45.38% vs 21.22% and 21.05%; prostate-specific antigen ≥20 ng/mL: 62.04% vs 17.29% and 11.17%, respectively; all 2-sided P < .0001). East over Southern African men are 1.5 times more likely to present with advanced disease, however, age was not a confounder. Supporting prostate cancer as a major health concern for Africa, our data suggest underestimation in East Africa, while highlighting the need for accurate monitoring, increased awareness, and tailored screening criteria. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/jnci/djaf117 |
| DOI: |
10.1093/jnci/djaf117/63135753/djaf117.pdf |
| Availability: |
https://doi.org/10.1093/jnci/djaf117; https://academic.oup.com/jnci/advance-article-pdf/doi/10.1093/jnci/djaf117/63135753/djaf117.pdf; https://academic.oup.com/jnci/article-pdf/117/12/2677/63135753/djaf117.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.2BB6437B |
| Database: |
BASE |