| Title: |
Five-year recurrence/survival after pancreatoduodenectomy for pancreatic adenocarcinoma: does pre-existing diabetes matter? Results from the Recurrence After Whipple's (RAW) study |
| Authors: |
Rajagopalan, A; Croagh, D; Aroori, S; Russell, TB; Labib, PL; Denson, J; Streeter, A; Puckett, M; Zhou, SM; Browning, M; Ausania, F; Gonzalez-Abos, C; Pando, E; Fernandes, N; Moller, EG; Taboada, CD; Roberts, KJ; Roberts, K; Pande, R; Alfarah, J; Kausar, A; Bandyopadhyay, S; Abdelrahim, A; Khan, A; Mavroeidis, VK; Jordan, C; Rees, JRE; Marangoni, G; Blege, H; Thomasset, SC; Cambridge, W; White, O; Frampton, AE; Frampton, A; Blacker, S; Blackburn, J; Sweeney, C; Lykoudis, P; Field, D; Gouda, M; Maglione, M; Bellotti, R; Alhaboob, N; Bari, H; Ahmed, H; Smith, AM; Smith, A; Moriarty, C; White, L; Priestley, M; Bode, K; Sharp, J; Wragg, R; Jackson, B; Craven, S; Spalding, D; Fehervari, M; Pai, M; Alghazawi, L; Onifade, A; Srinivasan, P; Ribaud, J; Nair, A; Mariathasan, M; Grayson, N; Davidson, BR; Davidson, B; Pericleous, S; Patel, K; Shaw, C; Morare, N; Zaban, MK; Bhogal, RH; Bhogal, R; Doyle, J; Dominguez, I; Thakkar, R; Jones, M; Buckley, E; Akter, N; Treherne, K; Gomez, D; Gordon, G; Silva, MA; Silva, M; Hughes, D; Urbonas, T; Lapolla, P; Mingoli, A; Porcu, A; Perra, T; Shah, NS; Abd Kahar, NN; Hall, T; Nadeem, N; Hamady, ZZR; Hamady, Z |
| Source: |
HPB , 26 (8) pp. 981-989. (2024) |
| Publisher Information: |
ELSEVIER SCI LTD |
| Publication Year: |
2024 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Pancreatic Neoplasms; Prognosis; Diabetes Mellitus; Pancreaticoduodenectomy |
| Description: |
BACKGROUND: Diabetes mellitus (DM) has a complex relationship with pancreatic cancer. This study examines the impact of preoperative DM, both recent-onset and pre-existing, on long-term outcomes following pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC). METHODS: Data were extracted from the Recurrence After Whipple's (RAW) study, a multi-centre cohort of PD for pancreatic head malignancy (2012–2015). Recurrence and five-year survival rates of patients with DM were compared to those without, and subgroup analysis performed to compare patients with recent-onset DM (less than one year) to patients with established DM. RESULTS: Out of 758 patients included, 187 (24.7%) had DM, of whom, 47 of the 187 (25.1%) had recent-onset DM. There was no difference in the rate of postoperative pancreatic fistula (DM: 5.9% vs no DM 9.8%; p = 0.11), five-year survival (DM: 24.1% vs no DM: 22.9%; p = 0.77) or five-year recurrence (DM: 71.7% vs no DM: 67.4%; p = 0.32). There was also no difference between patients with recent-onset DM and patients with established DM in postoperative outcomes, recurrence, or survival. CONCLUSION: We found no difference in five-year recurrence and survival between diabetic patients and those without diabetes. Patients with pre-existing DM should be evaluated for PD on a comparable basis to non-diabetic patients. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10210951/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10210951/1/Five-year%20recurrence%20survival%20after%20pancreatoduodenectomy%20for%20pancreatic%20adenocarcinoma%20-%20clean%20AAM.pdf; https://discovery.ucl.ac.uk/id/eprint/10210951/ |
| Rights: |
open |
| Accession Number: |
edsbas.2BD4C04C |
| Database: |
BASE |