| Title: |
Postoperative Serum Hyperamylasemia (POH) Adds Sequential Value to the Fistula Risk Score (FRS) in Predicting Pancreatic Fistula after Pancreatoduodenectomy |
| Authors: |
Bannone, Elisa; Marchegiani, Giovanni; Vollmer, Charles; Perri, Giampaolo; Procida, Giuseppa; Corvino, Gaetano; Peressotti, Sara; Vacca, Pier Giuseppe; Salvia, Roberto; Bassi, Claudio |
| Contributors: |
Bannone, Elisa; Marchegiani, Giovanni; Vollmer, Charle; Perri, Giampaolo; Procida, Giuseppa; Corvino, Gaetano; Peressotti, Sara; Vacca, Pier Giuseppe; Salvia, Roberto; Bassi, Claudio |
| Publication Year: |
2023 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Pancreatic Fistula; Pancreatoduodenectomy; Postoperative Serum Hyperamylasemia; Predicting Pancreatic Fistula |
| Description: |
Objective: To evaluate whether postoperative serum hyperamylasemia (POH), with drain fluid amylase (DFA) and C-reactive protein (CRP), improves the Fistula Risk Score (FRS) accuracy in assessing the risk of a postoperative pancreatic fistula (POPF). Summary background data: The FRS predicts POPF occurrence using intraoperative predictors with good accuracy but intrinsic limits. Methods: Outcomes of patients who underwent pancreaticoduodenectomies (PD) between 2016 and 2021 were evaluated across FRS risk zones and POH occurrence. POH consists of serum amylase activity greater than the upper limit of normal (52 U/l), persisting within the first 48 hours postoperatively (postoperative day -POD- 1 and 2). Results: Out of 905 PDs, some FRS elements, namely soft pancreatic texture (OR 11.6), pancreatic duct diameter (OR 0.80), high-risk pathological diagnosis (OR 1.54), but not higher blood loss (OR 0.99), were associated with POH. POH was an independent predictor of POPF, which occurred in 46.8% of POH cases (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35876366; info:eu-repo/semantics/altIdentifier/wos/WOS:001026207500035; volume:Publish Ahead of Print; journal:ANNALS OF SURGERY; https://hdl.handle.net/11577/3476934 |
| DOI: |
10.1097/SLA.0000000000005629 |
| Availability: |
https://hdl.handle.net/11577/3476934; https://doi.org/10.1097/SLA.0000000000005629 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Accesso libero |
| Accession Number: |
edsbas.2C58D430 |
| Database: |
BASE |