| Title: |
Epigenetic effects of benzene in hematologic neoplasms: The altered gene expression |
| Authors: |
Spatari G.; Allegra A.; Carrieri M.; Pioggia G.; Gangemi S. |
| Contributors: |
Spatari, G.; Allegra, A.; Carrieri, M.; Pioggia, G.; Gangemi, S. |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2021 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Air pollution; Benzene; Cancer; Epigenetic; Gene expression; Hematological malignancie; Leukemia; Lymphoma; Occupational disease |
| Description: |
Benzene carcinogenic ability has been reported, and chronic exposure to benzene can be one of the risk elements for solid cancers and hematological neoplasms. Benzene is acknowledged as a myelotoxin, and it is able to augment the risk for the onset of acute myeloid leukemia, myelodysplastic syndromes, aplastic anemia, and lymphomas. Possible mechanisms of benzene initiation of hematological tumors have been identified, as a genotoxic effect, an action on oxidative stress and inflammation and the provocation of immunosuppression. However, it is becoming evident that genetic alterations and the other causes are insufficient to fully justify several phenomena that influence the onset of hematologic malignancies. Acquired epigenetic alterations may participate with benzene leukemogenesis, as benzene may affect nuclear receptors, and provoke post-translational alterations at the protein level, thereby touching the function of regulatory proteins, comprising oncoproteins and tumor suppressor proteins. DNA hypomethylation correlates with stimulation of oncogenes, while the hypermethylation of CpG islands in promoter regions of specific tumor suppressor genes inhibits their transcription and stimulates the onset of tumors. The discovery of the systems of epigenetic induction of benzene-caused hematological tumors has allowed the possibility to operate with pharmacological interventions able of stopping or overturning the negative effects of benzene. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34069279; info:eu-repo/semantics/altIdentifier/wos/WOS:000654660600001; volume:13; issue:10; firstpage:2392; journal:CANCERS; https://hdl.handle.net/11577/3398344 |
| DOI: |
10.3390/cancers13102392 |
| Availability: |
https://hdl.handle.net/11577/3398344; https://doi.org/10.3390/cancers13102392 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.2C643ECB |
| Database: |
BASE |