| Title: |
Orchestrated centers for the production of proteins or “translation factories” |
| Authors: |
Crawford, Robert A.; Eastham, Matthew; Pool, Martin R.; Ashe, Mark P. |
| Contributors: |
Biotechnology and Biological Sciences Research Council |
| Source: |
WIREs RNA ; volume 15, issue 4 ; ISSN 1757-7004 1757-7012 |
| Publisher Information: |
Wiley |
| Publication Year: |
2024 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
The mechanics of how proteins are generated from mRNA is increasingly well understood. However, much less is known about how protein production is coordinated and orchestrated within the crowded intracellular environment, especially in eukaryotic cells. Recent studies suggest that localized sites exist for the coordinated production of specific proteins. These sites have been termed “translation factories” and roles in protein complex formation, protein localization, inheritance, and translation regulation have been postulated. In this article, we review the evidence supporting the translation of mRNA at these sites, the details of their mechanism of formation, and their likely functional significance. Finally, we consider the key uncertainties regarding these elusive structures in cells. This article is categorized under: Translation Translation > Mechanisms RNA Export and Localization > RNA Localization Translation > Regulation |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/wrna.1867 |
| Availability: |
https://doi.org/10.1002/wrna.1867; https://wires.onlinelibrary.wiley.com/doi/pdf/10.1002/wrna.1867 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.2C6EF0C0 |
| Database: |
BASE |