| Title: |
Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study |
| Authors: |
Dixon-Suen, Suzanne C; Lewis, Sarah J; Martin, Richard M; English, Dallas R; Boyle, Terry; Giles, Graham G; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Lush, Michael; Investigators, ABCTB; Ahearn, Thomas U; Ambrosone, Christine B; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Auvinen, Päivi; Beane Freeman, Laura E; Becher, Heiko; Beckmann, Matthias W; Behrens, Sabine; Bermisheva, Marina; Blomqvist, Carl; Bogdanova, Natalia V; Bojesen, Stig E; Bonanni, Bernardo; Brenner, Hermann; Brüning, Thomas; Buys, Saundra S; Camp, Nicola J; Campa, Daniele; Canzian, Federico; Castelao, Jose E; Cessna, Melissa H; Chang-Claude, Jenny; Chanock, Stephen J; Clarke, Christine L; Conroy, Don M; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Daly, Mary B; Devilee, Peter; Dörk, Thilo; Dwek, Miriam; Eccles, Diana M |
| Contributors: |
Baden Württemberg Ministry of Science, Research and Arts; Fonds Wetenschappelijk Onderzoek; National Breast Cancer Foundation; North Carolina University Cancer Research Fund; Helmholtz Society; Medical Research Council; Cancer Institute NSW; Dietmar-Hopp Foundation; Wellcome Trust; University Hospital of Erlangen; Research and Innovation Programme; National Institute of Environmental Health Sciences; National Institute for Health Research; California Teachers Study Steering Committee; Macedonian Academy of Sciences and Arts; University of Crete; Canadian Cancer Society Research Institute; Institut National Du Cancer; Hamburger Krebsgesellschaft; Cancer Council Western Australia; National Health Service; Breast Cancer Now; European Regional Development Fund; Cancer Research UK; Fondation de France; Freistaat Sachsen; Instituto de Investigacion Biomedica Galicia Sur; Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail; Agence Nationale de la Recherche; European Union's Horizon 2020 Research and Innovation Programme; Acción Estratégica de Salud del Instituto de Salud Carlos III; National Cancer Institute; Ligue Contre le Cancer; Herlev and Gentofte Hospital; Cancer Council Victoria; American Cancer Society; Genome Québec; Robert Bosch Stiftung; VicHealth; David F. and Margaret T. Grohne Family Foundation; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Sundhed og Sygdom, Det Frie Forskningsråd; Sheffield Experimental Cancer Medicine Centre; Chief Physician Johan Boserup and Lise Boserup Fund; Seventh Framework Programme; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance; Vetenskapsrådet; National Institutes of Health; Genome Canada; California Department of Public Health; Institute of the Ruhr University Bochum; H2020 European Research Council; Centers for Disease Control and Prevention's National Program of Cancer Registries; National Cancer Institute’s Surveillance, Epidemiology and End Results Program; Fru Berta Kamprads Stiftelse; Canadian Institutes of Health Research; Swedish Local hospital funds; Swedish Cancer Foundation; National Cancer Research Network; Claudia von Schilling Foundation for Breast Cancer Research; Grant for SZBCS study; Against Breast Cancer; German Breast Group GmbH; Gunnar Nilssons Cancerstiftelse; Ministère de l’Économie, Science et Innovation du Québec; Fondation du cancer du sein du Québec; Huntsman Cancer Foundation; Huntsman Cancer Institute; Centre International de Recherche sur le Cancer; Helsinki University Hospital Research Fund; Institut Gustave Roussy; Rudolf Bartling Foundation; Ministry of Science and Higher Education, Poland; Lower Saxonian Cancer Society; Robert and Kate Niehaus Clinical Cancer Genetics Initiative; European Commission; Bundesministerium für Bildung und Forschung; Friends of Hannover Medical School; University of Bristol; University of Utah; Utah Cancer Registry; Deutsche Krebshilfe; Institut National de la Santé et de la Recherche Médicale; Sigrid Juselius Foundation; Utah Population Database; Mutuelle Générale de l’Education Nationale; Associazione Italiana per la Ricerca sul Cancro; Russian Foundation for Basic Research; Hellenic Health Foundation; Stavros Niarchos Foundation; Norges Forskningsråd; Xerencia de Xestion Integrada de Vigo - SERGAS; Oak Foundation; Netherlands Cancer Registry; K.G. Jebsen Centre for Breast Cancer Research; Cancer Foundation Finland; Ministry of Science and Higher Education of the Russian Federation; National Institute for Health Research University College London Hospitals Biomedical Research Centre; Dutch Ministry of Public Health, Welfare and Sports; Consiglio Nazionale delle Ricerche; Institute of Cancer Research; Dutch Prevention Funds; Lon V Smith Foundation; South Eastern Norway Health Authority; Bert von Kantzows foundation; LK Research Funds; Cancerfonden; Victorian Cancer Agency; Gustav V Jubilee foundation; Consellería de Industria de la Xunta de Galicia; Karolinska Institutet; NIHR Bristol Biomedical Research Centre; Stockholms Läns Landsting; Ovarian Cancer Research Fund; Johanniter GmbH Bonn, Johanniter Krankenhaus; NIHR Manchester Biomedical Research Centre; Kuopion Yliopistollinen Sairaala; Ministerio de Sanidad, Servicios Sociales e Igualdad; Breast Cancer Research Foundation; Komen Foundation for the Cure; World Cancer Research Fund; Kreftforeningen; Statistics Netherlands; U.S. Department of Defense; Märit and Hans Rausings Initiative Against Breast Cancer; Zorg Onderzoek Nederland; Stichting Tegen Kanker; Ministerio de Economia y Competitividad, Xunta de Galicia; Victorian Health Promotion Foundation; KWF Kankerbestrijding; Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra; Victorian Breast Cancer Research Consortium; Health Research Fund; New South Wales Cancer Council; Itä-Suomen Yliopisto; Finnish Cancer Organizations; Cancer Fund of North Savo; National Health and Medical Research Council; Deutsches Krebsforschungszentrum; Biobanking and Biomolecular Resources Research Infrastructure |
| Source: |
British Journal of Sports Medicine ; volume 56, issue 20, page 1157-1170 ; ISSN 0306-3674 1473-0480 |
| Publisher Information: |
BMJ |
| Publication Year: |
2022 |
| Description: |
Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics. Methods We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105–377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (n snps =5) or sedentary time (n snps =6), or accelerometer-measured (n snps =1) or self-reported (n snps =5) vigorous physical activity. Results Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger). Conclusion Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/bjsports-2021-105132 |
| Availability: |
https://doi.org/10.1136/bjsports-2021-105132; https://syndication.highwire.org/content/doi/10.1136/bjsports-2021-105132 |
| Accession Number: |
edsbas.2C7D6ABF |
| Database: |
BASE |