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Changes in growth factors in polycystic ovarian syndrome ; Изменение факторов роста при синдроме поликистозных яичников

Title:	Changes in growth factors in polycystic ovarian syndrome ; Изменение факторов роста при синдроме поликистозных яичников
Authors:	E. A. Vasukova; E. K. Zaikova; O. V. Kalinina; I. V. Gorelova; I. V. Pyanova; E. V. Bogatyreva; E. Y. Vasilyeva; M. A. Kokina; E. N. Grineva; P. V. Popova; Е. А. Васюкова; Е. К. Зайкова; О. В. Калинина; И. В. Горелова; И. В. Пьянова; Е. В. Богатырева; Е. Ю. Васильева; М. А. Кокина; Е. Н. Гринева; П. В. Попова
Contributors:	The study was carried out with the support of the following source: State assignment No. 25, registration number 121031100288-5. In addition, to solve the problems of comparing the cytokine profile in women with PCOS and the control group, samples from the collection collected from participants of the study “Studying the effect of different methods of weight loss on fertility and microbiome of obese women and PCOS”, performed in 2018–2020, were used.; Исследование выполнено при поддержке следующего источника: государственное задание № 25, регистрационный номер 121031100288-5. Кроме того, для решения задач по сравнению цитокинового профиля у женщин с СПКЯ и контрольной группы использованы образцы из коллекции, собранной от участниц исследования «Изучение влияния разных способов снижения веса на фертильность и микробиом женщин с ожирением и СПКЯ», выполненного в 2018–2020 гг.
Source:	Translational Medicine; Том 10, № 2 (2023); 77-87 ; Трансляционная медицина; Том 10, № 2 (2023); 77-87 ; 2410-5155 ; 2311-4495
Publisher Information:	Almazov National Medical Research Centre, Saint Petersburg, Russia
Publication Year:	2023
Collection:	Translational Medicine (E-Journal) / Трансляционная медицина
Subject Terms:	VEGF A; EGF; FGF2; FLT3L; PCOS; PDGF AA; PDGF AB/BB; TNF-α
Description:	Background. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 10-15% of women of reproductive age. PCOS is often associated with metabolic disorders, type 2 diabetes, cardiovascular disease, and other complications. In recent years, angiogenesis has been widely discussed as an important factor in the pathogenesis of PCOS.Objective. To identify growth factors in women with PCOS compared with healthy women in normal and overweight subgroups.Design and methods. This case-control study carried out at the Almazov National Medical Research Centre (ANMRC) included 45 patients with PCOS (22 women with a body mass index (BMI) < 25 kg/m2 and 23 women with a BMI > 25 kg/m2) and 45 women with normal ovulation (22 women with a BMI < 25 kg/m2 and 23 women with a BMI > 25 kg/m2). Seven growth factors were analyzed in the plasma of patients.Results. Compared to the control group, normal weight women with PCOS had higher plasma levels of EGF (medians were 5.57 and 0 pg/ml, p = 0.040) and FLT3L (medians were 5.0 and 2.25 pg/ml, p = 0.018). Growth factors FGF 2 and TGF alpha were increased in women with PCOS both in overweight and normal weight subgroups (p 25 ...
Document Type:	article in journal/newspaper
File Description:	application/pdf
Language:	Russian
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DOI:	10.18705/2311-44952023-10-2-77-87
Availability:	https://transmed.almazovcentre.ru/jour/article/view/763; https://doi.org/10.18705/2311-44952023-10-2-77-87
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Accession Number:	edsbas.2C9790D3
Database:	BASE