| Title: |
Clinical Characterization of the Three Waves of COVID-19 Occurring in Southern Italy: Results of a Multicenter Cohort Study |
| Authors: |
Pisaturo M.; Russo A.; Pattapola V.; Astorri R.; Maggi P.; Numis F. G.; Gentile I.; Sangiovanni V.; Rossomando A.; Gentile V.; Calabria G.; Pisapia R.; Codella A. V.; Masullo A.; Iodice V.; Giolitto G.; Parrella R.; Dell'Aquila G.; Gambardella M.; Di Perna F.; Coppola N. |
| Contributors: |
Pisaturo, M.; Russo, A.; Pattapola, V.; Astorri, R.; Maggi, P.; Numis, F. G.; Gentile, I.; Sangiovanni, V.; Rossomando, A.; Gentile, V.; Calabria, G.; Pisapia, R.; Codella, A. V.; Masullo, A.; Iodice, V.; Giolitto, G.; Parrella, R.; Dell'Aquila, G.; Gambardella, M.; Di Perna, F.; Coppola, N. |
| Publication Year: |
2022 |
| Collection: |
IRIS Università degli Studi di Napoli Federico II |
| Subject Terms: |
clinical outcome; COVID-19; mortality; pandemic wave; SARS-CoV-2 |
| Description: |
Aims: To characterize patients hospitalized for COVID-19 in the three waves in Southern Italy. Methods: We conducted a multicenter observational cohort study involving seventeen COVID-19 Units in Campania, southern Italy: All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection from 28 February 2020 to 31 May 2021, were enrolled. Results: Two thousand and fifteen COVID-19 hospitalized patients were enrolled; 392 (19%) in the first wave, 917 (45%) in the second and 706 (35%) in the third wave. Patients showed a less severe clinical outcome in the first wave than in the second and third waves (73%, 65% and 72%, respectively; p = 0.003), but hospitalization expressed in days was longer in the first wave [Median (Q1–Q3): 17 (13–25) v.s. 14 (9–21) and 14 (9–19), respectively, p = 0.001)] and also mortality during hospitalization was higher in the first wave than in the second and third waves: 16.6% v.s. 11.3% and 6.5%, respectively (p = 0.0001). Multivariate analysis showed that older age [OR: 1.069, CI (1046–1092); p = 0.001], a worse Charlson comorbidity index [OR: 1042, CI (1233–1594; p = 0.0001] and enrolment during the first-wave [OR: 1.917, CI (1.054–3.485; p = 0.033] were predictors of mortality in hospitalized patients. Conclusions: Improved organization of the healthcare facilities and the increase in knowledge of clinical and therapeutic management have contributed to a trend in the reduction in mortality during the three waves of COVID-19. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000921167400001; volume:19; issue:23; journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; https://hdl.handle.net/11588/991237 |
| DOI: |
10.3390/ijerph192316003 |
| Availability: |
https://hdl.handle.net/11588/991237; https://doi.org/10.3390/ijerph192316003 |
| Accession Number: |
edsbas.2CE62842 |
| Database: |
BASE |