| Title: |
Attenuated PGC-1 alpha Isoforms following Endurance Exercise with Blood Flow Restriction |
| Authors: |
Conceicao, MS; Traina Chacon-Mikahil, MP; Telles, GD; Libardi, CA; Mendes Junior, EM; Vechin, FC; Lugnani De Andrade, AL; Gaspari, AF; Brum, PC; Cavaglieri, CR; Serag, S; Spiegelman, BM; Hawley, JA; Camera, DM |
| Publisher Information: |
American College of Sports Medicine |
| Publication Year: |
2016 |
| Collection: |
Liverpool John Moores University: LJMU Research Online |
| Subject Terms: |
RC1200 Sports Medicine |
| Description: |
Introduction: Exercise performed with blood flow restriction simultaneously enhances the acute responses to both myogenic and mitochondrial pathways with roles in training adaptation. We investigated isoform-specific gene expression of the peroxisome proliferator-activated receptor gamma (PPARG) coactivator 1 and selected target genes and proteins regulating skeletal muscle training adaptation. Methods: 9 healthy, untrained males participated in a randomized, counter-balanced, cross-over design in which each subject completed a bout of low-intensity endurance exercise performed with blood flow restriction (15 min cycling at 40% of VO2peak, BFR-EE), endurance exercise (30 min cycling at 70% of VO2peak, EE) or resistance exercise (4 x 10 repetitions of leg press at 70% of 1-repetition maximum, RE) separated by at least one week recovery. A single resting muscle biopsy (vastus lateralis) was obtained two weeks before the first exercise trial (rest) and 3 h after each boat. Results: Total PGC-1α mRNA abundance, along with all four isoforms, increased above rest with EE only (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1530-0315 |
| Relation: |
https://researchonline.ljmu.ac.uk/id/eprint/5434/1/Manuscript%20Response%20R2%20FINAL%2030.03.16.pdf; Conceicao, MS, Traina Chacon-Mikahil, MP, Telles, GD, Libardi, CA, Mendes Junior, EM, Vechin, FC, Lugnani De Andrade, AL, Gaspari, AF, Brum, PC, Cavaglieri, CR, Serag, S, Spiegelman, BM, Hawley, JA and Camera, DM (2016) Attenuated PGC-1 alpha Isoforms following Endurance Exercise with Blood Flow Restriction. Medicine and Science in Sports and Exercise, 48 (9). pp. 1699-1707. ISSN 1530-0315 |
| DOI: |
10.1249/MSS.0000000000000970 |
| Availability: |
https://researchonline.ljmu.ac.uk/id/eprint/5434/; https://researchonline.ljmu.ac.uk/id/eprint/5434/1/Manuscript%20Response%20R2%20FINAL%2030.03.16.pdf; https://doi.org/10.1249/MSS.0000000000000970 |
| Accession Number: |
edsbas.2D011D2F |
| Database: |
BASE |