| Title: |
Outcomes of Lung Transplantation for Cystic Fibrosis in the Setting of Extensively Drug-Resistant Organisms |
| Authors: |
Winstead, Ryan J.; Waldman, Georgina; Autry, Elizabeth B.; Evans, Rickey A.; Schadler, Aric; Kays, Lindsey; Baz, Maher; Anstead, Michael I.; Shafii, Alexis; Goetz, Megan E. |
| Source: |
Progress in Transplantation ; volume 29, issue 3, page 220-224 ; ISSN 1526-9248 2164-6708 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2019 |
| Description: |
Introduction: Since the largest study on extensively drug-resistant organisms and lung transplantation in patients with cystic fibrosis, there have been innovations and advancements in the treatment of Pseudomonas aeruginosa. Research Question: What differences exist for patients with cystic fibrosis with a history of extensively drug-resistant infections who undergo lung transplantation despite treatment advances with antimicrobial therapy? Study Design: Two-center, retrospective, cohort study conducted in 44 patients with cystic fibrosis chronically infected with extensively drug-resistant organisms who received a lung transplant from January 2008 through August 2016. Patients in the resistant cohort were chronically infected with pan-resistant P aeruginosa, polymyxin-sensitive only, or sensitive to 2 antibiotic classes (polymyxin plus one other); remaining patients with more susceptible P aeruginosa or no P aeruginosa remained in the control cohort. The primary outcome is a composite of patient survival, retransplantation, chronic lung allograft dysfunction, and acute rejection 12 months posttransplant. Categorical variables were analyzed using χ 2 testing. The independent samples t test was utilized for continuous variables. Results: There was no difference in the primary outcome (40% vs 37%, P = .831). Differences between patient survival (84% vs 95%, P = .487), the incidence of acute rejection (20% vs 33%, P = .323), and the incidence of chronic lung allograft rejection (12% vs 5%, P = .441) were not different between groups. Discussion: Recipients chronically infected with an extensively resistant P aeruginosa had similar outcomes compared to those infected with more sensitive organisms. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/1526924819853830 |
| Availability: |
https://doi.org/10.1177/1526924819853830; https://journals.sagepub.com/doi/pdf/10.1177/1526924819853830; https://journals.sagepub.com/doi/full-xml/10.1177/1526924819853830 |
| Rights: |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.2D08D0CF |
| Database: |
BASE |