Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe.
| Title: | Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe. |
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| Authors: | Benschop, Kimberley S M; Broberg, Eeva K; Hodcroft, Emma; Schmitz, Dennis; Albert, Jan; Baicus, Anda; Bailly, Jean-Luc; Baldvinsdottir, Gudrun; Berginc, Natasa; Blomqvist, Soile; Böttcher, Sindy; Brytting, Mia; Bujaki, Erika; Cabrerizo, Maria; Celma, Cristina; Cinek, Ondrej; Claas, Eric C J; Cremer, Jeroen; Dean, Jonathan; Dembinski, Jennifer L; Demchyshyna, Iryna; Diedrich, Sabine; Dudman, Susanne; Dunning, Jake; Dyrdak, Robert; Emmanouil, Mary; Farkas, Agnes; de Gascun, Cillian; Fournier, Guillaume; Georgieva, Irina; Gonzalez-Sanz, Ruben; van Hooydonk-Elving, Jolanda; Jääskeläinen, Anne J; Jancauskaite, Ruta; Keeren, Kathrin; Fischer, Thea K; Krokstad, Sidsel; Nikolaeva-Glomb, Lubomira; Novakova, Ludmila; Midgley, Sofie E; Mirand, Audrey; Molenkamp, Richard; Morley, Ursula; Mossong, Joël; Muralyte, Svajune; Murk, Jean-Luc; Nguyen, Trung; Nordbø, Svein A; Österback, Riikka; Pas, Suzan; Pellegrinelli, Laura; Pogka, Vassiliki; Prochazka, Birgit; Rainetova, Petra; van Ranst, Marc; Roorda, Lieuwe; Schuffenecker, Isabelle; Schuurman, Rob; Stoyanova, Asya; Templeton, Kate; Verweij, Jaco J; Voulgari-Kokota, Androniki; Vuorinen, Tytti; Wollants, Elke; Wolthers, Katja C; Zakikhany, Katherina; Neher, Richard; Harvala, Heli; Simmonds, Peter |
| Contributors: | 1 Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands 2 European Ctr Dis Prevent & Control, Stockholm, Sweden 3 Univ Basel, Biozentrum, Basel, Switzerland 4 Swiss Inst Bioinformat, Basel, Switzerland 5 Karolinska Univ Hosp, Stockholm, Sweden 6 Karolinska Inst, Stockholm, Sweden 7 Cantacuzino, Bucharest, Romania 8 CHU Clermont Ferrand, Natl Reference Ctr Enteroviruses & Parechoviruses, Clermont Ferrand, France 9 Landspitali Natl Univ Hosp, Reykjavik, Iceland 10 Natl Lab Hlth Environm & Food, Ljubljana, Slovenia 11 Natl Inst Hlth & Welf, Helsinki, Finland 12 Robert Koch Inst, Berlin, Germany 13 Publ Hlth Agcy Sweden, Solna, Sweden 14 Natl Publ Hlth Ctr, Budapest, Hungary 15 Inst Salud Carlos III, Madrid, Spain 16 Publ Hlth England, Colindale, England 17 Univ Oslo, Oslo, Norway 18 Oslo Univ Hosp, Oslo, Norway 19 Charles Univ Prague, Prague, Czech Republic 20 Leiden Univ Med Ctr, Leiden, Netherlands 21 Univ Coll Dublin, Dublin, Ireland 22 Norwegian Inst Publ Hlth, World Hlth Org Natl Polio Entero Reference Lab, Oslo, Norway 23 Minist Hlth Ukraine, Publ Hlth Ctr, Kiev, Ukraine 24 Hellenic Pasteur Inst, Athens, Greece 25 Lab Natl Sante, Dudelange, Luxembourg 26 Natl Ctr Infect & Parasit Dis, Sofia, Bulgaria 27 Microvida, Breda, Netherlands 28 Univ Helsinki, Helsinki, Finland 29 Helsinki Univ Hosp, Helsinki, Finland 30 Natl Publ Hlth Surveillance Lab, Vilnius, Lithuania 31 Nordsjaellands Univ Hosp, Hillerod, Denmark 32 Statens Serum Inst, Copenhagen, Denmark 33 Univ Copenhagen, Copenhagen, Denmark 34 Univ Hosp Trondheim, Trondheim, Norway 35 Natl Inst Publ Hlth, Prague, Czech Republic 36 Statens Serum Inst, Danish WHO Natl Reference Lab Poliovirus, Copenhagen, Denmark 37 Erasmus MC, Rotterdam, Netherlands 38 Elisabeth Tweesteden Hosp, Tilburg, Netherlands 39 Norwegian Univ Sci & Technol, Trondheim, Norway 40 Turku Univ Hosp, Turku, Finland 41 Univ Milan, Milan, Italy 42 Austrian Agcy Hlth & Food Safety, Vienna, Austria 43 Katholieke Univ Leuven, Rega Inst, Leuven, Belgium 44 Maasstad Ziekenhuis, Rotterdam, Netherlands 45 Hosp Civils Lyon, Ctr Biol Est, Lyon, France 46 Univ Med Ctr Utrecht, Utrecht, Netherlands 47 Natl Hlth Serv Scotland, Edinburgh, Midlothian, Scotland 48 Univ Turku, Turku, Finland 49 Amsterdam Univ Med Ctr, Amsterdam, Netherlands 50 UCL, London, England 51 Natl Hlth Serv, Colindale, England 52 Univ Oxford, Oxford, England |
| Source: | Emerging infectious diseases ; 27 ; 6 ; 1616 ; 1626 ; United Kingdom ; United States |
| Publisher Information: | Centers for Disease Control and Prevention (CDC) |
| Publication Year: | 2021 |
| Subject Terms: | Europe; European Non-Polio Enterovirus Network; Molecular epidemiology; Nextstrain; echovirus 30; enterovirus; epidemiological monitoring; evolutionary trajectory; genetic recombination; meningitis/encephalitis; neurological manifestations; viruses; whole-genome sequencing; Echovirus Infections; Enterovirus Infections; droit; socio |
| Description: | To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download ; In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections. ; Ministry of Health, Welfare and Sport, the Netherlands as part of the EV surveillance program of the National Institute for Public Health and the Environment European Union Horizon 2020 research and innovation program (COMPARE grant from Aristotle University of Thessaloniki, Greece) Wellcome Trust European Commission Belgian National Reference Center for Enteroviruses from the RIZIV/INAMI (National Institute for Health and Disability Insurance) HONOURs Horizon 2020 Marie Sklodowska-Curie Training Network |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | http://hdl.handle.net/2336/621898 |
| Availability: | http://hdl.handle.net/2336/621898 |
| Rights: | undefined |
| Accession Number: | edsbas.2D493C41 |
| Database: | BASE |