| Title: |
Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion |
| Authors: |
Marchingo, J.M.; Kan, A.; Sutherland, Robyn M.; Duffy, Ken R. |
| Publisher Information: |
American Association for the Advancement of Science |
| Publication Year: |
2014 |
| Collection: |
Maynooth University ePrints and eTheses Archive (National University of Ireland) |
| Description: |
Tcell responses are initiated by antigen and promoted by a range of costimulatory signals. Understanding how Tcells integrate alternative signal combinations and make decisions affecting immune response strength or tolerance poses a considerable theoretical challenge. Here, we report that Tcell receptor (TCR) and costimulatory signals imprint an early, cell-intrinsic, division fate,whereby cells effectively count through generations before returning automatically to a quiescent state. This autonomous program can be extended by cytokines. Signals from the TCR, costimulatory receptors, and cytokines add together using a linear division calculus, allowing the strength of a Tcell response to be predicted from the sum of the underlying signal components.These data resolve a long-standing costimulation paradox and provide a quantitative paradigm for therapeutically manipulating immune response strength. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0036-8075 |
| Relation: |
https://mural.maynoothuniversity.ie/id/eprint/8284/1/KD_antigens%202014.pdf; Marchingo, J.M., Kan, A., Sutherland, Robyn M. and Duffy, Ken R. (2014) Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion. Science, 346 (6213). pp. 1123-1127. ISSN 0036-8075 |
| Availability: |
https://mural.maynoothuniversity.ie/id/eprint/8284/; https://mural.maynoothuniversity.ie/id/eprint/8284/1/KD_antigens%202014.pdf |
| Rights: |
cc_by_nc_sa |
| Accession Number: |
edsbas.2D4B87E1 |
| Database: |
BASE |