| Title: |
Prevalence and Clinical Consequences of Colistin Heteroresistance and Evolution into Full Resistance in Carbapenem-Resistant Acinetobacter baumannii |
| Authors: |
Kon, Hadas; Hameir, Amichay; Nutman, Amir; Temkin, Elizabeth; Keren Paz, Alona; Lellouche, Jonathan; Schwartz, David; Weiss, David S.; Kaye, Keith S.; Daikos, George L.; Skiada, Anna; Durante-Mangoni, Emanuele; Dishon Benattar, Yael; Yahav, Dafna; Daitch, Vered; Bernardo, Mariano; Iossa, Domenico; Friberg, Lena E.; Theuretzbacher, Ursula; Leibovici, Leonard; Dickstein, Yaakov; Pollak, Dina; Mendelsohn, Sigal; Paul, Mical; Carmeli, Yehuda; Bitterman, Roni; Zayyad, Hiba; Koppel, Fidi; Zak-Doron, Yael; Altunin, Sergey; Andria, Nizar; Neuberger, Ami; Stern, Anat; Petersiel, Neta; Raines, Marina; Karban, Amir; Eliakim-Raz, Noa; Zusman, Oren; Elbaz, Michal; Atamna, Heyam; Babich, Tanya; Adler, Amos |
| Contributors: |
Babiker, Ahmed; EU AIDA grant |
| Source: |
Microbiology Spectrum ; volume 11, issue 3 ; ISSN 2165-0497 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2023 |
| Description: |
To our knowledge, this is the first large-scale study to report on HR in Gram-negative bacteria. We described the prevalence of colistin HR in a large sample of carbapenem-resistant A. baumannii isolates, the evolution of many colistin HR isolates to a resistant phenotype following colistin exposure and withdrawal, and the clinical consequences of colistin HR. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/spectrum.05093-22 |
| Availability: |
https://doi.org/10.1128/spectrum.05093-22; https://journals.asm.org/doi/pdf/10.1128/spectrum.05093-22 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.2D59EEE1 |
| Database: |
BASE |