| Title: |
Inducing ipsilateral motor‐evoked potentials in the biceps brachii muscle in healthy humans |
| Authors: |
Hu, Nijia; Tanel, Meghan; Baker, Stuart N.; Kidgell, Dawson J.; Walker, Simon |
| Publisher Information: |
John Wiley & Sons |
| Publication Year: |
2024 |
| Collection: |
JYX - Jyväskylä University Digital Archive / Jyväskylän yliopiston julkaisuarkisto |
| Subject Terms: |
motor-evoked potential; preach curl; reticulospinal tract; strength training; transcranial magnetic stimulation; School of Wellbeing; Hyvinvoinnin tutkimuksen yhteisö; voimaharjoittelu; lihakset; tuki- ja liikuntaelimet; elektromyografia; motoriikka; nuoret aikuiset |
| Description: |
To assess reticulospinal tract excitability, high-intensity transcranial magnetic stimulation (TMS) has been used to elicit ipsilateral motor-evoked potentials (iMEPs). However, there is no consensus on robust and valid methods for use in human studies. The present study proposes a standardized method for eliciting and analysing iMEPs in the biceps brachii. Twenty-four healthy young adults participated in this study. Electromyography (EMG) electrodes recorded contralateral MEPs (cMEPs) from the right and iMEPs from the left biceps brachii. A dynamic preacher curl task was used with ~15% of the subject's one-repetition maximum load. The protocol included maximal compound action potential (M-max) determination of the right biceps brachii muscle, TMS hotspot determination, and four sets of five repetitions where 100% stimulator output was delivered at an elbow angle of 110° of flexion. We normalized cMEP amplitude by M-max (% M-max) and iMEP by cMEP amplitude ratio (ICAR). Clear iMEPs above background EMG were observed in 21 subjects (88%, ICAR = .31 ± .19). Good-to-excellent agreement (intraclass correlation coefficient [ICC] = .795–1.000) and low bias (.01–.08 mV and .60–1.11 ms) were demonstrated when comparing two different analysis methods (i.e. fixed time-window vs. manual onset detection) to determine the cMEP and iMEP amplitude and latency, respectively. Most subjects demonstrated clear iMEPs above background EMG triggered at a pre-determined joint angle during a light-load dynamic preacher curl exercise. Similar results were obtained when comparing a single-trial manual identification of iMEP and a semi-automated time-window data analysis approach. ; peerReviewed |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; fulltext |
| Language: |
English |
| ISSN: |
0953-816X |
| Relation: |
European Journal of Neuroscience; Early View; 350528; https://doi.org/10.6084/m9.figshare.26349526.v1; Research Council of Finland; Suomen Akatemia; Hu, N., Tanel, M., Baker, S. N., Kidgell, D. J., & Walker, S. (2024). Inducing ipsilateral motor‐evoked potentials in the biceps brachii muscle in healthy humans. European Journal of Neuroscience , Early View . https://doi.org/10.1111/ejn.16548 |
| Availability: |
http://urn.fi/URN:NBN:fi:jyu-202410236465 |
| Rights: |
CC BY 4.0 ; © 2024 The Author(s). European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. ; openAccess ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.2D85F9C4 |
| Database: |
BASE |