| Title: |
MicroRNA-9: functional evolution of a conserved small regulatory RNA |
| Authors: |
Yuva-Aydemir, Yeliz; Simkin, Alfred; Gascon, Eduardo; Gao, Fen-Biao |
| Contributors: |
Department of Neurology |
| Source: |
RNA biology ; 8 ; 4 ; 557-64 |
| Publication Year: |
2022 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
Animals; Apoptosis; Biological Evolution; Cell Differentiation; Cell Movement; Cell Proliferation; Humans; MicroRNAs; Neoplasm Metastasis; Neoplasms; Neurogenesis; Neurology; Neuroscience and Neurobiology |
| Description: |
The functional significance of microRNA-9 (miR-9) during evolution is evidenced by its conservation at the nucleotide level from flies to humans but not its diverse expression patterns. Recent studies in several model systems reveal that miR-9 can regulate neurogenesis through its actions in neural or non-neural cell lineages. In vertebrates, miR-9 exerts diverse cell-autonomous effects on the proliferation, migration, and differentiation of neural progenitor cells by modulating different mRNA targets. In some developmental contexts, miR-9 suppresses apoptosis and is misregulated in several types of cancer cells, influencing proliferation or metastasis formation. Moreover, downregulation of miR-9 in postmitotic neurons is also implicated in some neurodegenerative diseases. Thus, miR-9 is emerging as an important regulator in development and disease through its ability to modulate different targets in a manner dependent on the developmental stage and the cellular context. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Link to Article in PubMed; http://dx.doi.org/10.4161/rna.8.4.16019; http://hdl.handle.net/20.500.14038/37740; https://escholarship.umassmed.edu/neuro_pp/414; 3316138; neuro_pp/414 |
| DOI: |
10.4161/rna.8.4.16019 |
| Availability: |
https://doi.org/10.4161/rna.8.4.16019; https://hdl.handle.net/20.500.14038/37740; https://escholarship.umassmed.edu/neuro_pp/414 |
| Accession Number: |
edsbas.2D915797 |
| Database: |
BASE |