| Title: |
Group- and Genotype-Specific Neutralizing Antibody Responses Against Respiratory Syncytial Virus in Infants and Young Children With Severe Pneumonia |
| Authors: |
Sande, Charles J.; Mutunga, Martin N.; Medley, Graham F.; Cane, Patricia A.; Nokes, D. James |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2013 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
VIRUSES |
| Description: |
The effect of genetic variation on the neutralizing antibody response to respiratory syncytial virus (RSV) is poorly understood. In this study, acute- and convalescent-phase sera were evaluated against different RSV strains. The proportion of individuals with homologous seroconversion was greater than that among individuals with heterologous seroconversion among those infected with RSV group A (50% vs 12.5%; P = .0005) or RSV group B (40% vs 8%; P = .008). Seroconversion to BA genotype or non-BA genotype test viruses was similar among individuals infected with non-BA virus (35% vs 50%; P = .4) or BA virus (50% vs 65%; P = .4). The RSV neutralizing response is group specific. The BA-associated genetic change did not confer an ability to escape neutralizing responses to previous non-BA viruses. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://jid.oxfordjournals.org/cgi/content/short/207/3/489; http://dx.doi.org/10.1093/infdis/jis700 |
| DOI: |
10.1093/infdis/jis700 |
| Availability: |
http://jid.oxfordjournals.org/cgi/content/short/207/3/489; https://doi.org/10.1093/infdis/jis700 |
| Rights: |
Copyright (C) 2013, Infectious Diseases Society of America |
| Accession Number: |
edsbas.2DD81830 |
| Database: |
BASE |