| Title: |
Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis |
| Authors: |
Saberi Hosnijeh, Fatemeh; Casabonne, Delphine; Nieters, Alexandra; Solans, Marta; Naudin, Sabine; Ferrari, Pietro; Mckay, James D.; Benavente, Yolanda; Weiderpass, Elisabete; Freisling, Heinz; Severi, Gianluca; Boutron Ruault, Marie Christine; Besson, Caroline M.; Agnoli, Claudia; Masala, Giovanna; Sacerdote, Carlotta; Tumino, Rosario; Huerta, Jośe Mariá; Amiano, Pilar; Rodriguez-Barranco, Miguel A.; Bonet, Catalina; Barricarte, Aurelio; Christakoudi, Sofia; Knuppel, Anika; Bueno-De-Mesquita, Bas H.; Schulze, Matthias B.; Kaaks, Rudolf; Canzian, Federico; Späth, Florentin; Jerkeman, Mats; Rylander, Charlotta; Tjønneland, Anne; Olsen, Anja; Borch, Kristin Benjaminsen; Vermeulen, Roel C.H. |
| Contributors: |
Centre international de Recherche sur le Cancer (CIRC); Institut Gustave Roussy (IGR); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Mode de vie, génétique et santé : études intégratives et transgénérationnelles (U1018 (Équipe 9) - CESP); Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP); AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; UFR Sciences de la santé Simone Veil (UVSQ Santé); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay; 179 2017SGR1085 Kræftens Bekæmpelse, DCS German Cancer Research Center, DKFZ Centre International de Recherche sur le Cancer, CIRC Wellcome Trust, WT: 205212/Z/16/Z National Research Council, NRC Medical Research Council, MRC: MR/M012190/1 Cancer Research UK, CRUK: 14136, C570/A11692, C570/A16491 World Cancer Research Fund, WCRF European Commission, EC Institut National de la Santé et de la Recherche Médicale, Inserm Bundesministerium für Bildung und Forschung, BMBF: 01EO1303 Cancerfonden Ministerie van Volksgezondheid, Welzijn en Sport, VWS Agència de Gestió d'Ajuts Universitaris i de Recerca, AGAUR Ligue Contre le Cancer Vetenskapsrådet, VR NordForsk Associazione Italiana per la Ricerca sul Cancro, AIRC Deutsche Krebshilfe Institut Gustave-Roussy Mutuelle Générale de l'Education Nationale, MGEN European Regional Development Fund, ERDF: ERC2009‐AdG 232997, PI13/00061, PI13/01162, PI14/01219, PI17/01280 Hellenic Health Foundation, HHF; Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR), CERCA Programme/Generalitat de Catalunya for institutional support, Grant/Award Number: 2017SGR1085; Associazione Italiana per la Ricerca sul Cancro‐AIRC‐Italy and National Research Council (Italy); Cancer Research UK, Grant/Award Numbers: 14136 (to EPIC‐Norfolk), C570/A11692, C570/A16491; Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), (Spain); Danish Cancer Society (Denmark); TRANSCAN/Dutch Cancer Society, Grant/Award Number: 179; NOVEL consortium; Dutch Ministry of Public Health, Welfare and Sports (VWS); Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); European Commission (DG‐SANCO); Federal Ministry of Education and Research (BMBF); German Cancer Aid; German Cancer Research Center (DKFZ); German Federal Ministry of Education and Research, Grant/Award Number: BMBF 01EO1303; German Institute of Human Nutrition Potsdam‐Rehbruecke, Nuthetal (Germany); Institut Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (France); International Agency for Research on Cancer; Ligue Natinale Contre le Cancer; LK Research Funds; Medical Research Council, Grant/Award Numbers: 1000143 (to EPIC‐Norfolk), MR/M012190/1 (to EPIC‐Oxford); Mutuelle Generale de l'Education Nationale; Netherlands Cancer Registry (NKR); Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Spanish Ministry of Economy and Competitiveness ‐ Carlos III Institute of Health cofunded by FEDER funds/European Regional Develpment Fund (ERDF) ‐ a way to build Europe, Grant/Award Numbers: PI13/00061 (to Granada), PI13/01162 (to EPIC‐Murcia), PI17/01280, PI14/01219 (to Barcelona); Statistics Netherlands (The Netherlands), Grant/Award Number: Grant number: ERC2009‐AdG 232997; Swedish Cancer Society; Swedish Research Council and County Councils of Skåne and Vasterbotten (Sweden); the Hellenic Health Foundation (Greece); Wellcome Trust, Grant/Award Number: 205212/Z/16/Z; World Cancer Research Fund (WCRF) Funding information |
| Source: |
ISSN: 0020-7136. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2021 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
prospective study; lymphoma; lifestyle; exposome-wide association study; exposome; [SDV.CAN]Life Sciences [q-bio]/Cancer; [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33128820; PUBMED: 33128820; PUBMEDCENTRAL: PMC8048490 |
| DOI: |
10.1002/ijc.33369 |
| Availability: |
https://hal.science/hal-03230906; https://hal.science/hal-03230906v1/document; https://hal.science/hal-03230906v1/file/Association%20between%20anthropometry%20and%20lifestyle%20factors%20and%20risk%20of.pdf; https://doi.org/10.1002/ijc.33369 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.2DE90E42 |
| Database: |
BASE |