| Title: |
Seroprevalence of Antibodies to SARS-CoV-2 in Guangdong Province, China between March to June 2020 |
| Authors: |
Xiao, C; Leung, NHL; Cheng, Y; Lei, H; Ling, S; Lin, X; Tao, R; Huang, X; Guan, W; Yang, Z; Cowling, BJ; Zanin, M; Wong, SS |
| Publisher Information: |
//www.mdpi.com/journal/pathogens; Switzerland |
| Publication Year: |
2021 |
| Collection: |
University of Hong Kong: HKU Scholars Hub |
| Subject Terms: |
SARS-CoV-2; Coronavirus disease 2019; Seroprevalence; Guangdong; China; Antibody |
| Description: |
Guangdong province, located in South China, is an important economic hub with a large domestic migrant population and was among the earliest areas to report COVID-19 cases outside of Wuhan. We conducted a cross-sectional, age-stratified serosurvey to determine the seroprevalence of antibodies against SARS-CoV-2 after the emergence of COVID-19 in Guangdong. We tested 14,629 residual serum samples that were submitted for clinical testing from 21 prefectures between March and June 2020 for SARS-CoV-2 antibodies using a magnetic particle based chemiluminescent enzyme immunoassay and validated the results using a pseudovirus neutralization assay. We found 21 samples positive for SARS-CoV-2 IgG, resulting in an estimated age- and sex-weighted seroprevalence of 0.15% (95% CI: 0.06–0.24%). The overall age-specific seroprevalence was 0.07% (95% CI: 0.01–0.24%) in persons up to 9 years old, 0.22% (95% CI: 0.03–0.79%) in persons aged 10–19, 0.16% (95% CI: 0.07–0.33%) in persons aged 20–39, 0.13% (95% CI: 0.03–0.33%) in persons aged 40–59 and 0.18% (95% CI: 0.07–0.40%) in persons ≥60 years old. Fourteen (67%) samples had pseudovirus neutralization titers to S-protein, suggesting most of the IgG-positive samples were true-positives. Seroprevalence of antibodies to SARS-CoV-2 was low, indicating that there were no hidden epidemics during this period. Vaccination is urgently needed to increase population immunity to SARS-CoV-2. ; published_or_final_version |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
34832661 |
| Relation: |
Pathogens; Pathogens, 2021, v. 10 n. 11, article no. 1505; article no. 1505; 330787; WOS:000725167200001; 11; PMC8619097; https://hub.hku.hk/handle/10722/309068; 10 |
| DOI: |
10.3390/pathogens10111505 |
| Availability: |
https://hub.hku.hk/handle/10722/309068; https://doi.org/10.3390/pathogens10111505 |
| Rights: |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| Accession Number: |
edsbas.2DFFDFFB |
| Database: |
BASE |