| Title: |
A genome-wide association search for type 2 diabetes genes in African Americans. |
| Authors: |
Palmer, ND; McDonough, CW; Hicks, PJ; Roh, BH; Wing, MR; An, SS; Hester, JM; Cooke, JN; Bostrom, MA; Rudock, ME; Talbert, ME; Lewis, JP; DIAGRAM Consortium; MAGIC Investigators; Ferrara, A; Lu, L; Ziegler, JT; Sale, MM; Divers, J; Shriner, D; Adeyemo, A; Rotimi, CN; Ng, MC; Langefeld, CD; Freedman, BI; Bowden, DW; Voight, BF; Scott, LJ; Steinthorsdottir, V; Morris, AP; Dina, C; Welch, RP; Zeggini, E; Huth, C; Aulchenko, YS; Thorleifsson, G; McCulloch, LJ; Ferreira, T; Grallert, H; Amin, N; Wu, G; Willer, CJ; Raychaudhuri, S; McCarroll, SA; Langenberg, C; Hofmann, OM; Dupuis, J; Qi, L; Segrè, AV; Van Hoek, M; Navarro, P; Ardlie, K; Balkau, B; Benediktsson, R; Bennett, AJ; Blagieva, R; Boerwinkle, E; Bonnycastle, LL; Boström, KB; Bravenboer, B; Bumpstead, S; Burtt, NP; Charpentier, G; Chines, PS; Cornelis, M; Couper, DJ; Crawford, G; Doney, AS; Elliott, KS; Elliott, AL; Erdos, MR; Fox, CS; Franklin, CS; Ganser, M; Gieger, C; Grarup, N; Green, T; Griffin, S; Groves, CJ; Guiducci, C; Hadjadj, S; Hassanali, N; Herder, C; Isomaa, B; Jackson, AU; Johnson, PR; Jørgensen, T; Kao, WH; Klopp, N; Kong, A; Kraft, P; Kuusisto, J; Lauritzen, T; Li, M; Lieverse, A; Lindgren, CM; Lyssenko, V; Marre, M; Meitinger, T; Midthjell, K; Morken, MA; Narisu, N; Nilsson, P; Owen, KR; Payne, F; Perry, JR; Petersen, AK; Platou, C; Proença, C; Prokopenko, I; Rathmann, W; Rayner, NW; Robertson, NR; Rocheleau, G; Roden, M; Sampson, MJ; Saxena, R; Shields, BM; Shrader, P; Sigurdsson, G; Sparsø, T; Strassburger, K; Stringham, HM; Sun, Q; Swift, AJ; Thorand, B; Tichet, J; Tuomi, T; Van Dam, RM; Van Haeften, TW; Van Herpt, T; Van Vliet-Ostaptchouk, JV; Walters, GB; Weedon, MN; Wijmenga, C; Witteman, J; Bergman, RN; Cauchi, S; Collins, FS; Gloyn, AL; Gyllensten, U; Hansen, T; Hide, WA; Hitman, GA; Hofman, A; Hunter, DJ; Hveem, K; Laakso, M; Mohlke, KL; Morris, AD; Palmer, CN; Pramstaller, PP; Rudan, I; Sijbrands, E; Stein, LD; Tuomilehto, J; Uitterlinden, A; Walker, M; Wareham, NJ; Watanabe, RM; Abecasis, GR; Boehm, BO; Campbell, H; Daly, MJ; Hattersley, AT; Hu, FB; Meigs, JB; Pankow, JS; Pedersen, O; Wichmann, HE; Barroso, I; Florez, JC; Frayling, TM; Groop, L; Sladek, R; Thorsteinsdottir, U; Wilson, JF; Illig, T; Froguel, P; Van Duijn, CM; Stefansson, K; Altshuler, D; Boehnke, M; McCarthy, MI; Soranzo, N; Wheeler, E; Glazer, NL; Bouatia-Naji, N; Mägi, R; Randall, J; Johnson, T; Elliott, P; Rybin, D; Henneman, P; Dehghan, A; Hottenga, JJ; Song, K; Goel, A; Egan, JM; Lajunen, T; Doney, A; Kanoni, S; Cavalcanti-Proença, C; Kumari, M; Timpson, NJ; Zabena, C; Ingelsson, E; An, P; O'Connell, J; Luan, J; Elliott, A; Roccasecca, RM; Pattou, F; Sethupathy, P; Ariyurek, Y; Barter, P; Beilby, JP; Ben-Shlomo, Y; Bergmann, S; Bochud, M; Bonnefond, A; Borch-Johnsen, K; Böttcher, Y; Brunner, E; Bumpstead, SJ; Chen, YD; Chines, P; Clarke, R; Coin, LJ; Cooper, MN; Crisponi, L; Day, IN; De Geus, EJ; Delplanque, J; Fedson, AC; Fischer-Rosinsky, A; Forouhi, NG; Frants, R; Franzosi, MG; Galan, P; Goodarzi, MO; Graessler, J; Grundy, S; Gwilliam, R; Hallmans, G; Hammond, N; Han, X; Hartikainen, AL; Hayward, C; Heath, SC; Hercberg, S; Hicks, AA; Hillman, DR; Hingorani, AD; Hui, J; Hung, J; Jula, A; Kaakinen, M; Kaprio, J; Kesaniemi, YA; Kivimaki, M; Knight, B; Koskinen, S; Kovacs, P; Kyvik, KO; Lathrop, GM; Lawlor, DA; Le Bacquer, O; Lecoeur, C; Li, Y; Mahley, R; Mangino, M; Manning, AK; Martínez-Larrad, MT; McAteer, JB; McPherson, R; Meisinger, C; Melzer, D; Meyre, D; Mitchell, BD; Mukherjee, S; Naitza, S; Neville, MJ; Oostra, BA; Orrù, M; Pakyz, R; Paolisso, G; Pattaro, C; Pearson, D; Peden, JF; Pedersen, NL; Perola, M; Pfeiffer, AF; Pichler, I; Polasek, O; Posthuma, D; Potter, SC; Pouta, A; Province, MA; Psaty, BM; Rice, K; Ripatti, S; Rivadeneira, F; Rolandsson, O; Sandbaek, A; Sandhu, M; Sanna, S; Sayer, AA; Scheet, P; Seedorf, U; Sharp, SJ; Shields, B; Sijbrands, EJ; Silveira, A; Simpson, L; Singleton, A; Smith, NL; Sovio, U; Swift, A; Syddall, H; Syvänen, AC; Tanaka, T; Tönjes, A; Uitterlinden, AG; Van Dijk, KW; Varma, D; Visvikis-Siest, S; Vitart, V; Vogelzangs, N; Waeber, G; Wagner, PJ; Walley, A; Ward, KL; Watkins, H; Wild, SH; Willemsen, G; Witteman, JC; Yarnell, JW; Zelenika, D; Zethelius, B; Zhai, G; Zhao, JH; Zillikens, MC; Borecki, IB; Loos, RJ; Meneton, P; Magnusson, PK; Nathan, DM; Williams, GH; Silander, K; Salomaa, V; Smith, GD; Bornstein, SR; Schwarz, P; Spranger, J; Karpe, F; Shuldiner, AR; Cooper, C; Dedoussis, GV; Serrano-Ríos, M; Lind, L; Palmer, LJ; Franks, PW; Ebrahim, S; Marmot, M; Wright, AF; Stumvoll, M; Hamsten, A; Buchanan, TA; Valle, TT; Rotter, JI; Siscovick, DS; Penninx, BW; Boomsma, DI; Deloukas, P; Spector, TD; Ferrucci, L; Cao, A; Scuteri, A; Schlessinger, D; Uda, M; Ruokonen, A; Jarvelin, MR; Waterworth, DM; Vollenweider, P; Peltonen, L; Mooser, V |
| Contributors: |
Medical Research Council (MRC) |
| Publisher Information: |
Public Library of Science |
| Publication Year: |
2011 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
Adult; African Americans; Aged; Case-Control Studies; Cohort Studies; Diabetes Mellitus; Type 2; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Meta-Analysis as Topic; Middle Aged; Polymorphism; Single Nucleotide; Validation Studies as Topic; DIAGRAM Consortium; MAGIC Investigators |
| Description: |
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
PLOS One; http://hdl.handle.net/10044/1/28917; https://dx.doi.org/10.1371/journal.pone.0029202; G0801056B; G0801056/1 |
| DOI: |
10.1371/journal.pone.0029202 |
| Availability: |
http://hdl.handle.net/10044/1/28917; https://doi.org/10.1371/journal.pone.0029202 |
| Rights: |
This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
| Accession Number: |
edsbas.2E4AA294 |
| Database: |
BASE |