| Title: |
The LRRK2 signalling system |
| Authors: |
Price, A; Manzoni, C; Cookson, MR; Lewis, PA |
| Source: |
Cell and Tissue Research (2018) |
| Publication Year: |
2018 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Kinase; LRRK2; Parkinson’s disease; ROCO protein; Signal transduction |
| Description: |
The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction pathways in which LRRK2 is involved, it has been challenging to generate a clear idea as to how mutations and disease associated variants in this gene are altered in disease. Understanding the events in which LRRK2 is involved at a systems level is therefore critical to fully understand the biology and pathobiology of this protein and is the subject of this review. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10049912/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10049912/1/LRRK2-signalling-system.pdf; https://discovery.ucl.ac.uk/id/eprint/10049912/ |
| Rights: |
open |
| Accession Number: |
edsbas.2E913503 |
| Database: |
BASE |