| Title: |
Soluble CD52 mediates immune suppression by human seminal fluid |
| Authors: |
Harrison, LC; Stone, NL; Bandala-Sanchez, E; Huntington, ND; McLachlan, RI; Rautela, J; O’Bryan, MK |
| Publisher Information: |
Frontiers Media SA |
| Publication Year: |
2024 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Seminal fluid provides for the carriage and nutrition of sperm, but also modulates immunity to prevent allo-rejection of sperm by the female. Immune suppression by seminal fluid has been associated with extracellular vesicles, originally termed prostasomes, which contain CD52, a glycosylated glycophosphoinositol-anchored peptide released from testicular epithelial cells. Previously, we reported that human T cell-derived CD52, bound to the danger-associated molecular pattern protein, high mobility group box 1 (HMGB1), suppresses T cell function via the inhibitory sialic acid-binding immunoglobulin-like lectin-10 (Siglec-10) receptor. Here we show that human seminal fluid contains high concentrations of CD52 complexed with HMGB1, which mediates T cell suppression indirectly via Siglec-7 on antigen-presenting cells. Proliferation of natural killer (NK) cells, which express Siglec-7 and play a key role in the immune defence of the uterus, was directly suppressed by seminal fluid CD52. These findings elucidate a critical function of seminal fluid to suppress cellular immunity and facilitate reproduction. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://hdl.handle.net/11343/359596 |
| Availability: |
https://hdl.handle.net/11343/359596 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.2EBEC881 |
| Database: |
BASE |