| Title: |
Duration of allergen immunotherapy for long-term efficacy in allergic rhinoconjunctivitis |
| Authors: |
Penagos, M; Eifan, AO; Durham, SR; Scadding, GW |
| Contributors: |
Cox, L |
| Source: |
290 ; 275 |
| Publisher Information: |
Springer Verlag |
| Publication Year: |
2018 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
Allergen immunotherapy; Allergic rhinitis; Biomarkers; Long term efficacy; Mechanisms; Subcutaneous; Sublingual |
| Subject Geographic: |
United Kingdom |
| Description: |
Rationale Subcutaneous and sublingual immunotherapy are effective for allergic rhinitis. An important question is whether allergen immunotherapy provides a sustained clinical effect after treatment cessation. In view of potential side effects, cost and the necessary patient commitment, long-term benefit is an important consideration for the recommendation of immunotherapy over standard pharmacotherapy. Purpose of review In this review, we analyse the existing evidence for long-term effects of both routes of administration in the context of double-blind, placebo-controlled, randomised clinical trials that included a follow-up phase of at least 1 year after treatment cessation. Recent findings Overall, evidence suggests that 3 years of either subcutaneous or sublingual immunotherapy result in clinical benefit and immunological changes consistent with allergen-specific tolerance sustained for at least 2–3 years after treatment cessation. Summary The data presented here support recommendations in international guidelines that both routes of administration should be continued for a minimum of 3 years. Gaps in the evidence remain regarding the long-term efficacy of immunotherapy for perennial rhinitis and studies performed in children. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Current Treatment Options in Allergy; http://hdl.handle.net/10044/1/64310 |
| DOI: |
10.1007/s40521-018-0176-2 |
| Availability: |
http://hdl.handle.net/10044/1/64310; https://doi.org/10.1007/s40521-018-0176-2 |
| Rights: |
© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Accession Number: |
edsbas.2EFAB99 |
| Database: |
BASE |