| Title: |
Plasma asymmetric dimethylarginine and mortality in patients with acute decompensation of chronic heart failure |
| Authors: |
Zairis, Michael N; Patsourakos, Nikoloas G; Tsiaousis, George Z; Theodossis Georgilas, Anastassios; Melidonis, Andreas; Makrygiannis, Stamatis S; Velissaris, Dimitrios; Batika, Pelagia C; Argyrakis, Kyriakos S; Tzerefos, Stavros P; Prekates, Athanasios A; Foussas, Stefanos G |
| Publisher Information: |
British Medical Journal Publishing Group |
| Publication Year: |
2012 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Heart failure |
| Description: |
Objectives To investigate the prognostic value of circulating levels of asymmetric dimethylarginine (ADMA) in patients with acute decompensation of (New York Heart Association (NYHA) class III/IV) chronic heart failure and reduced left ventricular ejection fraction. Design Single-centre prospective observational study. Setting Tertiary referral centre. Patients A total of 651 consecutive and eligible hospitalised patients were studied. Patients were divided into four groups according to the quartiles of circulating levels of ADMA upon presentation. Main outcome measures Incidence of in-hospital (or 7-day in the case of prolonged hospitalisation), 31-day and 1-year cardiac mortality were the pre-specified study end points. Results Cumulative rates of in-hospital, 31-day and 1-year cardiac mortality were 10.6%, 18.7% and 36.4%, respectively. There was a gradual increased risk of in-hospital (p for trend =0.011), 31-day (p for trend =0.044) and 1-year (p for trend |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://heart.bmj.com/cgi/content/short/98/11/860; http://dx.doi.org/10.1136/heartjnl-2011-301372 |
| DOI: |
10.1136/heartjnl-2011-301372 |
| Availability: |
http://heart.bmj.com/cgi/content/short/98/11/860; https://doi.org/10.1136/heartjnl-2011-301372 |
| Rights: |
Copyright (C) 2012, BMJ Publishing Group Ltd |
| Accession Number: |
edsbas.2F1FA23C |
| Database: |
BASE |