| Title: |
P-422: Outcomes in patients not receiving add-on therapy in the study on cognition and prognosis in the elderly (scope) |
| Authors: |
Zanchetti, Alberto; Skoog, Ingmar; Elmfeldt, Dag; Hofman, Albert; Olofsson, Bertil; Trenkwalder, Peter; Lithell, Hans |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2004 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
The Study on COgnition and Prognosis in the Elderly (SCOPE) was the first large-scale clinical trial to determine the effects of angiotensin II type 1 receptor blockade on cardiovascular and cognitive outcomes in elderly patients with mild to moderate hypertension. The present analysis evaluates clinical outcomes in SCOPE in patients who did not receive add-on antihypertensive therapy after randomization, i.e. in patients that best reflect the original intention of a placebo controlled trial. Patients randomized in SCOPE were aged 70–89 years, with systolic blood pressure 160–179 mmHg and/or diastolic blood pressure 90–99 mmHg, and preserved cognitive function. Out of 4,937 patients in SCOPE, 2,098 did not receive add-on therapy, and of these 1,253 patients received candesartan 8–16 mg once daily, and 845 placebo. Mean follow-up was 3.7 and 3.5 years, respectively. The primary outcome measure in SCOPE was major cardiovascular events, defined as the composite of cardiovascular mortality, non-fatal stroke and non-fatal myocardial infarction. Secondary outcomes included total mortality, cardiovascular mortality, and cognitive function. The treatment groups were generally well balanced for baseline characteristics. Blood pressure fell by 21.8/11.0 mmHg with candesartan and by 17.2/8.4 mmHg with placebo (difference between groups 4.7/2.6 mmHg, p |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://ajh.oxfordjournals.org/cgi/content/short/17/S1/188A-a; http://dx.doi.org/10.1016/j.amjhyper.2004.03.496 |
| DOI: |
10.1016/j.amjhyper.2004.03.496 |
| Availability: |
http://ajh.oxfordjournals.org/cgi/content/short/17/S1/188A-a; https://doi.org/10.1016/j.amjhyper.2004.03.496 |
| Rights: |
Copyright (C) 2004, American Journal of Hypertension, Ltd. |
| Accession Number: |
edsbas.2F4EA137 |
| Database: |
BASE |