| Title: |
31P multi-echo MRSI with low B1+ dual-band refocusing RF pulses |
| Authors: |
Shams, Zahra; van der Kemp, Wybe J.M.; Klomp, Dennis W.J.; Wiegers, Evita C.; Wijnen, Jannie P.; Cancer; Highfield Research Group; Precision Imaging Group; Regenerative Medicine and Stem Cells; Brain; Center for Image Sciences; Child Health; Infection & Immunity |
| Publication Year: |
2025 |
| Subject Terms: |
dual-band refocusing pulse; increased SNR per unit of time; low-power RF pulse; phosphorus multi-echo MRSI; PME and PDE detection; ultra-high field MRSI; Molecular Medicine; Radiology Nuclear Medicine and imaging; Spectroscopy |
| Description: |
31P magnetic resonance spectroscopy (MRS) can spectrally resolve metabolites involved in phospholipid metabolism whose levels are altered in many cancers. Ultra-high field facilitates the detection of phosphomonoesters (PMEs) and phosphodiesters (PDEs) with increased SNR and spectral resolution. Utilizing multi-echo MR spectroscopic imaging (MRSI) further enhances SNR and enables T2 information estimation per metabolite. To address the specific absorption rate (SAR) challenges associated with high-power demanding adiabatic or composite block pulses in multi-echo phosphorus imaging, we present a dual-band refocusing RF pulse designed for operation at B1 amplitudes of 14.8 μT which holds potential for integration into multi-echo sequences. Phantom and in vivo experiments conducted in the brain at 7 Tesla validated the effectiveness of this low-power dual-band RF pulse. Furthermore, we implemented the dual-band RF pulse into a multi-echo MRSI sequence where it offered the potential to increase the number of echo pulses within the same acquisition time compared to high-power adiabatic implementation, demonstrating its feasibility and practicality. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0952-3480 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/458549 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/458549 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.2F6674B6 |
| Database: |
BASE |