| Title: |
Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study |
| Authors: |
Sundström, Johan; Risérus, Ulf; Byberg, Liisa; Zethelius, Björn; Lithell, Hans; Lind, Lars |
| Publisher Information: |
BMJ Publishing Group Ltd |
| Publication Year: |
2006 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
RESEARCH |
| Description: |
Objectives To find out if the presence of the metabolic syndrome increases the risk of subsequent total and cardiovascular mortality, taking into account established risk factors for cardiovascular disease. Design Prospective cohort study. Setting General population. Participants A community based sample of 2322 men followed since 1970 for a maximum of 32.7 years, investigated at ages 50 and 70. Main outcome measures The relations of the metabolic syndrome defined by the national cholesterol education programme (NCEP) of the US National Heart, Lung, and Blood Institute or criteria of the World Health Organization (WHO) to subsequent total and cardiovascular mortality. Results When adding the metabolic syndrome to models with established risk factors for cardiovascular disease (smoking, diabetes, hypertension, and serum cholesterol) at age 50, presence of the metabolic syndrome as defined in the NCEP significantly predicted total and cardiovascular mortality (Cox proportional hazard ratios 1.36, 95% confidence interval 1.17 to 1.58; and 1.59, 1.29 to 1.95, respectively). The metabolic syndrome added prognostic information to that of the established risk factors for cardiovascular disease (likelihood ratio tests, P |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://www.bmj.com/cgi/content/short/bmj.38766.624097.1Fv1; http://dx.doi.org/10.1136/bmj.38766.624097.1F |
| DOI: |
10.1136/bmj.38766.624097.1F |
| Availability: |
http://www.bmj.com/cgi/content/short/bmj.38766.624097.1Fv1; https://doi.org/10.1136/bmj.38766.624097.1F |
| Rights: |
Copyright (C) 2006, BMJ Publishing Group Ltd |
| Accession Number: |
edsbas.2F6B9B92 |
| Database: |
BASE |