| Title: |
Abnormal Brain MRI in Anti-NMDA Receptor Encephalitis |
| Authors: |
Khatib, Laura; Pique, Julie; Ciano-Petersen, Nicolas, Lundahl; Criton, Guillaume; Birzu, Cristina; Aubart, Mélodie; Benaiteau, Marie; Picard, Geraldine; Marignier, Romain; Carra-Dalliere, Clarisse; Ayrignac, Xavier; Psimaras, Dimitri; Labauge, Pierre, M; Honnorat, Jerome; Cotton, Francois; Joubert, Bastien |
| Contributors: |
CHU Montpellier = Montpellier University Hospital; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Institut des Neurosciences de Montpellier (INM); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle (MIRCEM); Hospices Civils de Lyon (HCL); Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina = Biomedical Research Institute of Málaga and Nanomedicine Platform (IBIMA Plataforma BIONAND); Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon); Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Institut du Cerveau = Paris Brain Institute (ICM); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS); Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Mécanismes en sciences intégratives du vivant (MeLiS); Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Université de Lyon; Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL); Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Forgetting Processes and Cortical Dynamics (CRNL-FORGETTING); Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL); Plateforme de Neurobiologie Moléculaire, Cellulaire et Tissulaire (CRNL-GenCyTi); This work has been developed within the BETPSY project, which is supported by a public grant overseen by the Agence Nationale de la Recherche (ANR) as part of the secondInvestissements d’Avenir programme (ANR-18-RHUS-0012) and has been performed within the framework of the LABEX CORTEX (ANR-11-LABX-0042) of the Université de Lyon operated by the ANR. The study is supported by the European Reference Network RITA.; ANR-18-RHUS-0012,BETPSY,Biomarkers in autoimmune EncephaliTis and Paraneoplastic neurological SYndromes(2018); ANR-11-LABX-0042,CORTEX,Construction, Fonction Cognitive et Réhabilitation du Cerveau(2011) |
| Source: |
ISSN: 2332-7812 ; Neurology Neuroimmunology & Neuroinflammation ; https://u-paris.hal.science/hal-05110245 ; Neurology Neuroimmunology & Neuroinflammation, 2025, 12 (3), pp.e200378. ⟨10.1212/NXI.0000000000200378⟩. |
| Publisher Information: |
CCSD; American Academy of neurology |
| Publication Year: |
2025 |
| Subject Terms: |
MESH: Humans; MESH: Anti-N-Methyl-D-Aspartate Receptor Encephalitis; MESH: Adolescent; MESH: Follow-Up Studies; MESH: Aged; MESH: Male; MESH: Female; MESH: Magnetic Resonance Imaging; MESH: Retrospective Studies; MESH: Adult; MESH: Middle Aged; MESH: Prognosis; MESH: Young Adult; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background and objectives: Abnormal brain MRI is associated with poor outcomes in anti-N-methyl-d-aspartate receptor encephalitis (NMDARE). We aimed to characterize the lesions on brain MRI in NMDARE and to assess the clinical and prognostic associations.Methods: This retrospective cohort study included patients with NMDARE identified at the French Reference Center for Autoimmune Encephalitis, with at least a one-year follow-up, and with available brain MRI results. In case of brain extralimbic lesion, the image files were reviewed when available. Clinical data were collected from medical records. Multivariable logistic regression analysis was used to study the outcomes at 2-year follow-up; recovery was defined as modified Rankin Scale score ≤1.Results: Among the 255 patients included, 37 (14.5%) had limbic hyperintensities and 41 (16.1%) had extralimbic lesions that included multiple sclerosis (MS)-like lesions (14/41, 34.1%); extensive lesions (5/41, 12.2%); and poorly demarcated fluffy lesions, either multifocal (10/41, 24.4%) or involving the cerebral cortex or cerebellum (6/41 each, 14.6%). Extralimbic lesions coexisting with limbic lesions (19/41 patients, 46.3%) were mostly fluffy lesions (11/19, 57.9%). Ten patients had overlapping demyelinating syndromes: 4 with MS, 4 with myelin oligodendrocyte glycoprotein-associated disorder, and 2 with neuromyelitis optica spectrum disorder; all had MS-like (7/10 patients) or extensive (3/10 patients) lesions, and none had fluffy lesions. Extralimbic lesions were associated with symptoms nontypical for NMDARE (23/41, 56.1%, p < 0.001), especially cerebellar ataxia (17/41, 41.5%) and motor impairment (12/41, 29.3%). At 2 years, patients with MS-like or extensive lesions had a lower recovery rate (5/12, 41.7%, and 1/4, 25%, respectively) compared with the patients without extralimbic lesions (124/162, 76.5%; p = 0.014 and p = 0.047, respectively). In multivariable analysis, MS-like lesions, but not hippocampal nor fluffy lesions, were ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39999393; PUBMED: 39999393; PUBMEDCENTRAL: PMC11867192 |
| DOI: |
10.1212/NXI.0000000000200378 |
| Availability: |
https://u-paris.hal.science/hal-05110245; https://u-paris.hal.science/hal-05110245v1/document; https://u-paris.hal.science/hal-05110245v1/file/khatib-et-al-2025-abnormal-brain-mri-in-anti-nmda-receptor-encephalitis.pdf; https://doi.org/10.1212/NXI.0000000000200378 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.2F7DEC2A |
| Database: |
BASE |