| Title: |
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations |
| Authors: |
Haslam, DE; Peloso, GM; Guirette, M; Imamura, F; Bartz, TM; Pitsillides, AN; Wang, CA; Li-Gao, R; Westra, JM; PitkA nen, N; Young, KL; Graff, M; Wood, AC; Braun, KVE; Luan, J; KA hA nen, M; Kiefte-De Jong, JC; Ghanbari, M; Tintle, N; Lemaitre, RN; Mook-Kanamori, DO; North, K; Helminen, M; Mossavar-Rahmani, Y; Snetselaar, L; Martin, LW; Viikari, JS; Oddy, WH; Pennell, CE; Rosendall, FR; Ikram, MA; Uitterlinden, AG; Psaty, BM; Mozaffarian, D; Rotter, JI; Taylor, KD; LehtimA ki, T; Raitakari, OT; Livingston, KA; Voortman, T; Forouhi, NG; Wareham, NJ; De Mutsert, R; Rich, SS; Manson, JAE; Mora, S; Ridker, PM; Merino, J; Meigs, JB; Dashti, HS |
| Publisher Information: |
Lippincott Williams & Wilkins |
| Publication Year: |
2021 |
| Subject Terms: |
Biomedical and Clinical Sciences; Nutrition and dietetics; Food properties (incl. characteristics and health benefits); envir |
| Description: |
Background: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia. Methods: Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake. Results: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele; P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://ecite.utas.edu.au/152442/1/152438 - The role of environmental exposure to non-cigarette smoke in lung disease.pdf; https://doi.org/10.1161/CIRCGEN.120.003288 |
| DOI: |
10.1161/CIRCGEN.120.003288 |
| Availability: |
http://ecite.utas.edu.au/152442/1/152438 - The role of environmental exposure to non-cigarette smoke in lung disease.pdf; https://doi.org/10.1161/CIRCGEN.120.003288 |
| Rights: |
undefined |
| Accession Number: |
edsbas.2FAC50AE |
| Database: |
BASE |