| Title: |
Sporadic multiple intracranial meningioma does not infer worse patient outcomes: results from a case control study |
| Authors: |
Islim, AI; Lee, JX; Mustafa, MA; Millward, CP; Gillespie, CS; Richardson, GE; Taweel, BA; Chavredakis, E; Mills, SJ; Brodbelt, AR; Jenkinson, MD |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2023 |
| Collection: |
The University of Liverpool Repository |
| Description: |
Background: Sporadic multiple meningioma are uncommon. Population-based data suggests that these patients have a reduced overall survival when compared to patients with solitary meningioma. The aim of this study was to investigate the clinical outcomes in multiple and solitary meningioma. Methods: A single-center matched cohort study (2008–2018) was performed. Patients with synchronous multiple meningioma at presentation, with no history of prior intracranial radiation, concurrent hormone replacement therapy or features of NF2-schwannomatosis were included. Eligible patients were matched 1:1 to patients with solitary meningioma. Outcomes of interest were occurrence of an intervention, recurrence, new meningioma development and mortality. Results: Thirty-four patients harboring 76 meningioma at presentation were included. Mean age was 59.3 years (SD = 13.5). Thirty-one (91.2%) were female. The median number of meningioma per patient was 2 (range 2–6). Eighteen patients (52.9%) were symptomatic at presentation. Median overall follow-up was 80.6 months (IQR 44.1–99.6). Compared to patients with a sporadic meningioma, there was no difference in intervention rates (67.6% vs 70.6%, P = 0.792). Eight patients (34.8%) with a multiple meningioma had a WHO grade 2 meningioma compared to 7 (29.2%) with a solitary meningioma (P = 0.679). Median recurrence-free survival was 89 months (95% CI 76–104) with no difference between the two groups (P = 0.209). Mean overall survival was 132 months (95% CI 127–138) with no difference between the two groups (P = 0.860). One patient with multiple meningioma developed two further new meningioma 36 months following diagnosis. Conclusion: Sporadic multiple meningioma may not have worse clinical outcomes. Management of patients with sporadic multiple meningioma should be tailored towards the symptomatic meningioma or high-risk asymptomatic meningioma. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0167-594X |
| Relation: |
https://livrepository.liverpool.ac.uk/3170959/1/2022_Mutliple%20meningioma_paper.docx; Collapse authors list. Islim, AI, Lee, JX, Mustafa, MA, Millward, CP orcid:0000-0001-7727-1157 , Gillespie, CS, Richardson, GE, Taweel, BA orcid:0000-0002-6157-2438 , Chavredakis, E, Mills, SJ orcid:0000-0002-1017-6654 , Brodbelt, AR et al (show 1 more authors) and Jenkinson, MD orcid:0000-0003-4587-2139 (2023) Sporadic multiple intracranial meningioma does not infer worse patient outcomes: results from a case control study Journal of Neuro Oncology, 161 (2). pp. 287-295. ISSN 0167-594X, 1573-7373 |
| DOI: |
10.1007/s11060-022-04184-4 |
| Availability: |
https://livrepository.liverpool.ac.uk/3170959/; https://doi.org/10.1007/s11060-022-04184-4; https://livrepository.liverpool.ac.uk/3170959/1/2022_Mutliple%20meningioma_paper.docx |
| Accession Number: |
edsbas.2FBEC8A0 |
| Database: |
BASE |