Reduced 8-Gray Compared to Standard 12-Gray Total Body Irradiation for Allogeneic Transplantation in First Remission Acute Lymphoblastic Leukemia: A Study of the Acute Leukemia Working Party of the EBMT
| Title: | Reduced 8-Gray Compared to Standard 12-Gray Total Body Irradiation for Allogeneic Transplantation in First Remission Acute Lymphoblastic Leukemia: A Study of the Acute Leukemia Working Party of the EBMT |
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| Authors: | Spyridonidis A.; Labopin M.; Savani B.; Giebel S.; Bug G.; Schonland S.; Kroger N.; Stelljes M.; Schroeder T.; Mcdonald A.; Blau I. -W.; Bornhauser M.; Rovira M.; Bethge W.; Neubauer A.; Ganser A.; Bourhis J. H.; Edinger M.; Lioure B.; Wulf G.; Schafer-Eckart K.; Arat M.; Peric Z.; Schmid C.; Bazarbachi A.; Ciceri F.; Nagler A.; Mohty M. |
| Contributors: | Spyridonidis, A.; Labopin, M.; Savani, B.; Giebel, S.; Bug, G.; Schonland, S.; Kroger, N.; Stelljes, M.; Schroeder, T.; Mcdonald, A.; Blau, I. -W.; Bornhauser, M.; Rovira, M.; Bethge, W.; Neubauer, A.; Ganser, A.; Bourhis, J. H.; Edinger, M.; Lioure, B.; Wulf, G.; Schafer-Eckart, K.; Arat, M.; Peric, Z.; Schmid, C.; Bazarbachi, A.; Ciceri, F.; Nagler, A.; Mohty, M. |
| Publisher Information: | Wolters Kluwer Health |
| Publication Year: | 2023 |
| Description: | In this registry-based study, we compared outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) in adult patients with acute lymphoblastic leukemia (ALL) transplanted in first complete remission (CR-1), following conditioning with total body irradiation (TBI) at a standard 12-Gray or at a lower 8-Gray total dose. Patients received fludarabine (flu) as the sole chemotherapy complementing TBI. Eight-Gray TBI/flu was used in 494 patients and 12-Gray TBI/flu in 145 patients. Eighty-eight (23.1%) and 36 (29%) of the patients had Ph-negative B-ALL, 222 (58.3%) and 53 (42.7%) had Ph-positive B-ALL, 71 (18.6%) and 35 (28.2%) T-ALL, respectively (P = 0.008). Patients treated with 8-Gray were older than ones received 12-Gray (median 55.7 versus 40.3 years, P < 0.0001) and were more frequently administered in vivo T-cell depletion (71% versus 40%, P |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000940863500001; volume:7; issue:1; numberofpages:9; journal:HEMASPHERE; https://hdl.handle.net/20.500.11768/138356; https://journals.lww.com/hemasphere/Fulltext/2023/01000/Reduced_8_Gray_Compared_to_Standard_12_Gray_Total.11.aspx |
| DOI: | 10.1097/HS9.0000000000000812 |
| Availability: | https://hdl.handle.net/20.500.11768/138356; https://doi.org/10.1097/HS9.0000000000000812; https://journals.lww.com/hemasphere/Fulltext/2023/01000/Reduced_8_Gray_Compared_to_Standard_12_Gray_Total.11.aspx |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.2FECA127 |
| Database: | BASE |